2020


A Guide to Plasma Membrane Solute Carrier Proteins
Pizzagalli MD, Bensimon A, Superti-Furga G.
FEBS J. 2020 Aug 18. doi: 10.1111/febs.15531. Online ahead of print. PMID: 32810346

eIF2B as a Target for Viral Evasion of PKR-Mediated Translation Inhibition
Wuerth JD, Habjan M, Kainulainen M, Berisha B, Bertheloot D, Superti-Furga G, Pichlmair A, Weber F.
mBio. 2020 Jul 14;11(4):e00976-20. doi: 10.1128/mBio.00976-20. PMID: 32665273

A substrate-based ontology for human solute carriers
Meixner E, Goldmann U, Sedlyarov V, Scorzoni S, Rebsamen M, Girardi E, Superti-Furga G.
Mol Syst Biol. 2020 Jul;16(7):e9652. doi: 10.15252/msb.20209652. PMID: 32697042

The RESOLUTE consortium: unlocking SLC transporters for drug discovery
Superti-Furga G, Lackner D, Wiedmer T, Ingles-Prieto A, Barbosa B, Girardi E, Goldmann U, Gürtl B, Klavins K, Klimek C, Lindinger S, Liñeiro-Retes E, Müller AC, Onstein S, Redinger G, Reil D, Sedlyarov V, Wolf G, Crawford M, Everley R, Hepworth D, Liu S, Noell S, Piotrowski M, Stanton R, Zhang H, Corallino S, Faedo A, Insidioso M, Maresca G, Redaelli L, Sassone F, Scarabottolo L, Stucchi M, Tarroni P, Tremolada S, Batoulis H, Becker A, Bender E, Chang YN, Ehrmann A, Müller-Fahrnow A, Pütter V, Zindel D, Hamilton B, Lenter M, Santacruz D, Viollet C, Whitehurst C, Johnsson K, Leippe P, Baumgarten B, Chang L, Ibig Y, Pfeifer M, Reinhardt J, Schönbett J, Selzer P, Seuwen K, Bettembourg C, Biton B, Czech J, de Foucauld H, Didier M, Licher T, Mikol V, Pommereau A, Puech F, Yaligara V, Edwards A, Bongers BJ, Heitman LH, IJzerman AP, Sijben HJ, van Westen GJP, Grixti J, Kell DB, Mughal F, Swainston N, Wright-Muelas M, Bohstedt T, Burgess-Brown N, Carpenter L, Dürr K, Hansen J, Scacioc A, Banci G, Colas C, Digles D, Ecker G, Füzi B, Gamsjäger V, Grandits M, Martini R, Troger F, Altermatt P, Doucerain C, Dürrenberger F, Manolova V, Steck AL, et al.
Nat Rev Drug Discov. 2020 Jul;19(7):429-430. doi: 10.1038/d41573-020-00056-6. PMID: 32265506

Caught in the genetic network: a novel regulator of lipid metabolism
Girardi E, Superti-Furga G.
Nat Metab. 2020 Jun;2(6):483-484. doi: 10.1038/s42255-020-0218-5. PMID: 32694730

Targeted Degradation of SLC Transporters Reveals Amenability of Multi-Pass Transmembrane Proteins to Ligand-Induced Proteolysis
Bensimon A, Pizzagalli MD, Kartnig F, Dvorak V, Essletzbichler P, Winter GE, Superti-Furga G.
Cell Chem Biol. 2020 Jun 18;27(6):728-739.e9. doi: 10.1016/j.chembiol.2020.04.003. Epub 2020 May 7. PMID: 32386596

TASL is the SLC15A4-associated adaptor for IRF5 activation by TLR7-9
Heinz LX, Lee J, Kapoor U, Kartnig F, Sedlyarov V, Papakostas K, César-Razquin A, Essletzbichler P, Goldmann U, Stefanovic A, Bigenzahn JW, Scorzoni S, Pizzagalli MD, Bensimon A, Müller AC, King FJ, Li J, Girardi E, Mbow ML, Whitehurst CE, Rebsamen M, Superti-Furga G.
Nature. 2020 May;581(7808):316-322. doi: 10.1038/s41586-020-2282-0. Epub 2020 May 13. PMID: 32433612

A widespread role for SLC transmembrane transporters in resistance to cytotoxic drugs
Girardi E, César-Razquin A, Lindinger S, Papakostas K, Konecka J, Hemmerich J, Kickinger S, Kartnig F, Gürtl B, Klavins K, Sedlyarov V, Ingles-Prieto A, Fiume G, Koren A, Lardeau CH, Kumaran Kandasamy R, Kubicek S, Ecker GF, Superti-Furga G.
Nat Chem Biol. 2020 Apr;16(4):469-478. doi: 10.1038/s41589-020-0483-3. Epub 2020 Mar 9. PMID: 32152546

Patient-derived model systems and the development of next-generation anticancer therapeutics
Krall N, Superti-Furga G, Vladimer GI.
Curr Opin Chem Biol. 2020 Jun;56:72-78. doi: 10.1016/j.cbpa.2020.01.002. Epub 2020 Feb 18. PMID: 32086157



2019


Genome-scale CRISPR screens are efficient in non-homologous end-joining deficient cells
Ferreira da Silva J, Salic S, Wiedner M, Datlinger P, Essletzbichler P, Hanzl A, Superti-Furga G, Bock C, Winter G, Loizou JI.
Sci Rep. 2019 Oct 31;9(1):15751. doi: 10.1038/s41598-019-52078-9. PMID: 31673055

Common Nodes of Virus-Host Interaction Revealed Through an Integrated Network Analysis
Bösl K, Ianevski A, Than TT, Andersen PI, Kuivanen S, Teppor M, Zusinaite E, Dumpis U, Vitkauskiene A, Cox RJ, Kallio-Kokko H, Bergqvist A, Tenson T, Merits A, Oksenych V, Bjørås M, Anthonsen MW, Shum D, Kaarbø M, Vapalahti O, Windisch MP, Superti-Furga G, Snijder B, Kainov D, Kandasamy RK.
Front Immunol. 2019 Oct 4;10:2186. doi: 10.3389/fimmu.2019.02186. eCollection 2019. PMID: 31636628

Polymerase δ deficiency causes syndromic immunodeficiency with replicative stress
Conde CD, Petronczki ÖY, Baris S, Willmann KL, Girardi E, Salzer E, Weitzer S, Ardy RC, Krolo A, Ijspeert H, Kiykim A, Karakoc-Aydiner E, Förster-Waldl E, Kager L, Pickl WF, Superti-Furga G, Martínez J, Loizou JI, Ozen A, van der Burg M, Boztug K.
J Clin Invest. 2019 Oct 1;129(10):4194-4206. doi: 10.1172/JCI128903. PMID: 31449058

Transcriptional Responses to IFN-γ Require Mediator Kinase-Dependent Pause Release and Mechanistically Distinct CDK8 and CDK19 Functions
Steinparzer I, Sedlyarov V, Rubin JD, Eislmayr K, Galbraith MD, Levandowski CB, Vcelkova T, Sneezum L, Wascher F, Amman F, Kleinova R, Bender H, Andrysik Z, Espinosa JM, Superti-Furga G, Dowell RD, Taatjes DJ, Kovarik P.
Mol Cell. 2019 Nov 7;76(3):485-499.e8. doi: 10.1016/j.molcel.2019.07.034. Epub 2019 Sep 5. PMID: 31495563

The transporters SLC35A1 and SLC30A1 play opposite roles in cell survival upon VSV virus infection
Moskovskich A, Goldmann U, Kartnig F, Lindinger S, Konecka J, Fiume G, Girardi E, Superti-Furga G.
Sci Rep. 2019 Jul 18;9(1):10471. doi: 10.1038/s41598-019-46952-9. PMID: 31320712

Insights into the transport side of the human SLC38A9 transceptor
Scalise M, Galluccio M, Pochini L, Cosco J, Trotta M, Rebsamen M, Superti-Furga G, Indiveri C.
Biochim Biophys Acta Biomembr. 2019 Sep 1;1861(9):1558-1567. doi: 10.1016/j.bbamem.2019.07.006. Epub 2019 Jul 8. PMID: 31295473

IRF1 is critical for the TNF-driven interferon response in rheumatoid fibroblast-like synoviocytes : JAKinibs suppress the interferon response in RA-FLSs
Bonelli M, Dalwigk K, Platzer A, Olmos Calvo I, Hayer S, Niederreiter B, Holinka J, Sevelda F, Pap T, Steiner G, Superti-Furga G, Smolen JS, Kiener HP, Karonitsch T.
Exp Mol Med. 2019 Jul 8;51(7):75. doi: 10.1038/s12276-019-0267-6. PMID: 31285419

The phosphatase UBASH3B/Sts-1 is a negative regulator of Bcr-Abl kinase activity and leukemogenesis
Mian AA, Baumann I, Liebermann M, Grebien F, Superti-Furga G, Ruthardt M, Ottmann OG, Hantschel O.
Leukemia. 2019 Sep;33(9):2319-2323. doi: 10.1038/s41375-019-0468-y. Epub 2019 Apr 8. PMID: 30962580

Combined chemosensitivity and chromatin profiling prioritizes drug combinations in CLL
Schmidl C, Vladimer GI, Rendeiro AF, Schnabl S, Krausgruber T, Taubert C, Krall N, Pemovska T, Araghi M, Snijder B, Hubmann R, Ringler A, Runggatscher K, Demirtas D, de la Fuente OL, Hilgarth M, Skrabs C, Porpaczy E, Gruber M, Hoermann G, Kubicek S, Staber PB, Shehata M, Superti-Furga G, Jäger U, Bock C.
Nat Chem Biol. 2019 Mar;15(3):232-240. doi: 10.1038/s41589-018-0205-2. Epub 2019 Jan 28. PMID: 30692684

FOXO3 is involved in the tumor necrosis factor-driven inflammatory response in fibroblast-like synoviocytes
Brandstetter B, Dalwigk K, Platzer A, Niederreiter B, Kartnig F, Fischer A, Vladimer GI, Byrne RA, Sevelda F, Holinka J, Pap T, Steiner G, Superti-Furga G, Smolen JS, Kiener HP, Karonitsch T.
Lab Invest. 2019 May;99(5):648-658. doi: 10.1038/s41374-018-0184-7. Epub 2019 Jan 24. PMID: 30679758

Systematic genetic mapping of necroptosis identifies SLC39A7 as modulator of death receptor trafficking
Fauster A, Rebsamen M, Willmann KL, César-Razquin A, Girardi E, Bigenzahn JW, Schischlik F, Scorzoni S, Bruckner M, Konecka J, Hörmann K, Heinz LX, Boztug K, Superti-Furga G.
Cell Death Differ. 2019 Jun;26(6):1138-1155. doi: 10.1038/s41418-018-0192-6. Epub 2018 Sep 20. PMID: 30237509



2018


LZTR1 is a regulator of RAS ubiquitination and signaling
Bigenzahn JW, Collu GM, Kartnig F, Pieraks M, Vladimer GI, Heinz LX, Sedlyarov V, Schischlik F, Fauster A, Rebsamen M, Parapatics K, Blomen VA, Müller AC, Winter GE, Kralovics R, Brummelkamp TR, Mlodzik M, Superti-Furga G.
Science. 2018 Dec 7;362(6419):1171-1177. doi: 10.1126/science.aap8210. Epub 2018 Nov 15. PMID: 30442766

NSs Protein of Sandfly Fever Sicilian Phlebovirus Counteracts Interferon (IFN) Induction by Masking the DNA-Binding Domain of IFN Regulatory Factor 3
Wuerth JD, Habjan M, Wulle J, Superti-Furga G, Pichlmair A, Weber F.
J Virol. 2018 Nov 12;92(23):e01202-18. doi: 10.1128/JVI.01202-18. Print 2018 Dec 1. PMID: 30232186

In silico Prioritization of Transporter-Drug Relationships From Drug Sensitivity Screens
César-Razquin A, Girardi E, Yang M, Brehme M, Saez-Rodriguez J, Superti-Furga G.
Front Pharmacol. 2018 Sep 7;9:1011. doi: 10.3389/fphar.2018.01011. eCollection 2018. PMID: 30245630

Recent advances in combinatorial drug screening and synergy scoring
Pemovska T, Bigenzahn JW, Superti-Furga G.
Curr Opin Pharmacol. 2018 Oct;42:102-110. doi: 10.1016/j.coph.2018.07.008. Epub 2018 Sep 5. PMID: 30193150

Identifying the druggable interactome of EWS-FLI1 reveals MCL-1 dependent differential sensitivities of Ewing sarcoma cells to apoptosis inducers
Tsafou K, Katschnig AM, Radic-Sarikas B, Mutz CN, Iljin K, Schwentner R, Kauer MO, Mühlbacher K, Aryee DNT, Westergaard D, Haapa-Paananen S, Fey V, Superti-Furga G, Toretsky J, Brunak S, Kovar H.
Oncotarget. 2018 Jul 24;9(57):31018-31031. doi: 10.18632/oncotarget.25760. eCollection 2018 Jul 24. PMID: 30123424

Detection of Chemical Engagement of Solute Carrier Proteins by a Cellular Thermal Shift Assay
Hashimoto M, Girardi E, Eichner R, Superti-Furga G.
ACS Chem Biol. 2018 Jun 15;13(6):1480-1486. doi: 10.1021/acschembio.8b00270. Epub 2018 Jun 6. PMID: 29851333

MLL-fusion-driven leukemia requires SETD2 to safeguard genomic integrity
Skucha A, Ebner J, Schmöllerl J, Roth M, Eder T, César-Razquin A, Stukalov A, Vittori S, Muhar M, Lu B, Aichinger M, Jude J, Müller AC, Győrffy B, Vakoc CR, Valent P, Bennett KL, Zuber J, Superti-Furga G, Grebien F.
Nat Commun. 2018 May 18;9(1):1983. doi: 10.1038/s41467-018-04329-y. PMID: 29777171

The Bicarbonate Transporter SLC4A7 Plays a Key Role in Macrophage Phagosome Acidification
Sedlyarov V, Eichner R, Girardi E, Essletzbichler P, Goldmann U, Nunes-Hasler P, Srndic I, Moskovskich A, Heinz LX, Kartnig F, Bigenzahn JW, Rebsamen M, Kovarik P, Demaurex N, Superti-Furga G.
Cell Host Microbe. 2018 Jun 13;23(6):766-774.e5. doi: 10.1016/j.chom.2018.04.013. Epub 2018 May 17. PMID: 29779931

mTOR Senses Environmental Cues to Shape the Fibroblast-like Synoviocyte Response to Inflammation
Karonitsch T, Kandasamy RK, Kartnig F, Herdy B, Dalwigk K, Niederreiter B, Holinka J, Sevelda F, Windhager R, Bilban M, Weichhart T, Säemann M, Pap T, Steiner G, Smolen JS, Kiener HP, Superti-Furga G.
Cell Rep. 2018 May 15;23(7):2157-2167. doi: 10.1016/j.celrep.2018.04.044. PMID: 29768212

Proteogenomic Analysis to Identify Missing Proteins from Haploid Cell Lines
Lee SE, Song J, Bösl K, Müller AC, Vitko D, Bennett KL, Superti-Furga G, Pandey A, Kandasamy RK, Kim MS.
Proteomics. 2018 Apr;18(8):e1700386. doi: 10.1002/pmic.201700386. PMID: 29474001



2017


Proposed Terminology and Classification of Pre-Malignant Neoplastic Conditions: A Consensus Proposal
Valent P, Akin C, Arock M, Bock C, George TI, Galli SJ, Gotlib J, Haferlach T, Hoermann G, Hermine O, Jäger U, Kenner L, Kreipe H, Majeti R, Metcalfe DD, Orfao A, Reiter A, Sperr WR, Staber PB, Sotlar K, Schiffer C, Superti-Furga G, Horny HP.
EBioMedicine. 2017 Dec;26:17-24. doi: 10.1016/j.ebiom.2017.11.024. Epub 2017 Nov 26. PMID: 29203377

Image-based ex-vivo drug screening for patients with aggressive haematological malignancies: interim results from a single-arm, open-label, pilot study
Snijder B, Vladimer GI, Krall N, Miura K, Schmolke AS, Kornauth C, Lopez de la Fuente O, Choi HS, van der Kouwe E, Gültekin S, Kazianka L, Bigenzahn JW, Hoermann G, Prutsch N, Merkel O, Ringler A, Sabler M, Jeryczynski G, Mayerhoefer ME, Simonitsch-Klupp I, Ocko K, Felberbauer F, Müllauer L, Prager GW, Korkmaz B, Kenner L, Sperr WR, Kralovics R, Gisslinger H, Valent P, Kubicek S, Jäger U, Staber PB, Superti-Furga G.
Lancet Haematol. 2017 Dec;4(12):e595-e606. doi: 10.1016/S2352-3026(17)30208-9. Epub 2017 Nov 15. PMID: 29153976

LAMTOR/Ragulator is a negative regulator of Arl8b- and BORC-dependent late endosomal positioning
Filipek PA, de Araujo MEG, Vogel GF, De Smet CH, Eberharter D, Rebsamen M, Rudashevskaya EL, Kremser L, Yordanov T, Tschaikner P, Fürnrohr BG, Lechner S, Dunzendorfer-Matt T, Scheffzek K, Bennett KL, Superti-Furga G, Lindner HH, Stasyk T, Huber LA.
J Cell Biol. 2017 Dec 4;216(12):4199-4215. doi: 10.1083/jcb.201703061. Epub 2017 Oct 9. PMID: 28993467

Sustained activation of the AKT/mTOR and MAP kinase pathways mediate resistance to the Src inhibitor, dasatinib, in thyroid cancer
Mishall KM, Beadnell TC, Kuenzi BM, Klimczak DM, Superti-Furga G, Rix U, Schweppe RE.
Oncotarget. 2017 Aug 24;8(61):103014-103031. doi: 10.18632/oncotarget.20488. eCollection 2017 Nov 28. PMID: 29262541

Nilotinib-induced vasculopathy: identification of vascular endothelial cells as a primary target site
Hadzijusufovic E, Albrecht-Schgoer K, Huber K, Hoermann G, Grebien F, Eisenwort G, Schgoer W, Herndlhofer S, Kaun C, Theurl M, Sperr WR, Rix U, Sadovnik I, Jilma B, Schernthaner GH, Wojta J, Wolf D, Superti-Furga G, Kirchmair R, Valent P.
Leukemia. 2017 Nov;31(11):2388-2397. doi: 10.1038/leu.2017.245. Epub 2017 Jul 31. PMID: 28757617

Lapatinib potentiates cytotoxicity of  YM155 in neuroblastoma via inhibition of the ABCB1 efflux transporter
Radic-Sarikas B, Halasz M, Huber KVM, Winter GE, Tsafou KP, Papamarkou T, Brunak S, Kolch W, Superti-Furga G.
Sci Rep. 2017 Jun 8;7(1):3091. doi: 10.1038/s41598-017-03129-6. PMID: 28596528

Corrigendum: NANS-mediated synthesis of sialic acid is required for brain and skeletal development
van Karnebeek CDM, Bonafé L, Wen XY, Tarailo-Graovac M, Balzano S, Royer-Bertrand B, Ashikov A, Garavelli L, Mammi I, Turolla L, Breen C, Donnai D, Cormier V, Heron D, Nishimura G, Uchikawa S, Campos-Xavier B, Rossi A, Hennet T, Brand-Arzamendi K, Rozmus J, Harshman K, Stevenson BJ, Girardi E, Superti-Furga G, Dewan T, Collingridge A, Halparin J, Ross CJ, Van Allen MI, Rossi A, Engelke UF, Kluijtmans LAJ, van der Heeft E, Renkema H, de Brouwer A, Huijben K, Zijlstra F, Heisse T, Boltje T, Wasserman WW, Rivolta C, Unger S, Lefeber DJ, Wevers RA, Superti-Furga A.
Nat Genet. 2017 May 26;49(6):969. doi: 10.1038/ng0617-969a. PMID: 28546570

Global survey of the immunomodulatory potential of common drugs
Vladimer GI, Snijder B, Krall N, Bigenzahn JW, Huber KVM, Lardeau CH, Sanjiv K, Ringler A, Berglund UW, Sabler M, de la Fuente OL, Knöbl P, Kubicek S, Helleday T, Jäger U, Superti-Furga G.
Nat Chem Biol. 2017 Jun;13(6):681-690. doi: 10.1038/nchembio.2360. Epub 2017 Apr 24. PMID: 28437395

TKI rotation-induced persistent deep molecular response in multi-resistant blast crisis of Ph+ CML
Valent P, Herndlhofer S, Schneeweiß M, Boidol B, Ringler A, Kubicek S, Gleixner KV, Hoermann G, Hadzijusufovic E, Müllauer L, Sperr WR, Superti-Furga G, Mannhalter C.
Oncotarget. 2017 Apr 4;8(14):23061-23072. doi: 10.18632/oncotarget.15481. PMID: 28416739

Next generation of network medicine: interdisciplinary signaling approaches
Korcsmaros T, Schneider MV, Superti-Furga G.
Integr Biol (Camb). 2017 Feb 20;9(2):97-108. doi: 10.1039/c6ib00215c. PMID: 28106223

Artemisinins Target GABA(A) Receptor Signaling and Impair α Cell Identity
Li J, Casteels T, Frogne T, Ingvorsen C, Honoré C, Courtney M, Huber KVM, Schmitner N, Kimmel RA, Romanov RA, Sturtzel C, Lardeau CH, Klughammer J, Farlik M, Sdelci S, Vieira A, Avolio F, Briand F, Baburin I, Májek P, Pauler FM, Penz T, Stukalov A, Gridling M, Parapatics K, Barbieux C, Berishvili E, Spittler A, Colinge J, Bennett KL, Hering S, Sulpice T, Bock C, Distel M, Harkany T, Meyer D, Superti-Furga G, Collombat P, Hecksher-Sørensen J, Kubicek S.
Cell. 2017 Jan 12;168(1-2):86-100.e15. doi: 10.1016/j.cell.2016.11.010. Epub 2016 Dec 1. PMID: 27916275

Combinatorial Drug Screening Identifies Ewing Sarcoma-specific Sensitivities
Radic-Sarikas B, Tsafou KP, Emdal KB, Papamarkou T, Huber KV, Mutz C, Toretsky JA, Bennett KL, Olsen JV, Brunak S, Kovar H, Superti-Furga G.
Mol Cancer Ther. 2017 Jan;16(1):88-101. doi: 10.1158/1535-7163.MCT-16-0235. Epub 2016 Nov 15. PMID: 28062706

NDEL1-PDGFRB fusion gene in a myeloid malignancy with eosinophilia associated with resistance to tyrosine kinase inhibitors
Byrgazov K, Kastner R, Gorna M, Hoermann G, Koenig M, Lucini CB, Ulreich R, Benesch M, Strenger V, Lackner H, Schwinger W, Sovinz P, Haas OA, van den Heuvel-Eibrink M, Niemeyer CM, Hantschel O, Valent P, Superti-Furga G, Urban C, Dworzak MN, Lion T.
Leukemia. 2017 Jan;31(1):237-240. doi: 10.1038/leu.2016.250. Epub 2015 Aug 30. PMID: 27573554



2016


Heme drives hemolysis-induced susceptibility to infection via disruption of phagocyte functions
Martins R, Maier J, Gorki AD, Huber KV, Sharif O, Starkl P, Saluzzo S, Quattrone F, Gawish R, Lakovits K, Aichinger MC, Radic-Sarikas B, Lardeau CH, Hladik A, Korosec A, Brown M, Vaahtomeri K, Duggan M, Kerjaschki D, Esterbauer H, Colinge J, Eisenbarth SC, Decker T, Bennett KL, Kubicek S, Sixt M, Superti-Furga G, Knapp S.
Nat Immunol. 2016 Dec;17(12):1361-1372. doi: 10.1038/ni.3590. Epub 2016 Oct 31. PMID: 27798618

Reciprocal stabilization of ABL and TAZ regulates osteoblastogenesis through transcription factor RUNX2
Matsumoto Y, La Rose J, Kent OA, Wagner MJ, Narimatsu M, Levy AD, Omar MH, Tong J, Krieger JR, Riggs E, Storozhuk Y, Pasquale J, Ventura M, Yeganeh B, Post M, Moran MF, Grynpas MD, Wrana JL, Superti-Furga G, Koleske AJ, Pendergast AM, Rottapel R.
J Clin Invest. 2016 Dec 1;126(12):4482-4496. doi: 10.1172/JCI87802. Epub 2016 Oct 31. PMID: 27797343

A time-resolved molecular map of the macrophage response to VSV infection
Kandasamy RK, Vladimer GI, Snijder B, Müller AC, Rebsamen M, Bigenzahn JW, Moskovskich A, Sabler M, Stefanovic A, Scorzoni S, Brückner M, Penz T, Cleary C, Kralovics R, Colinge J, Bennett KL, Superti-Furga G.
NPJ Syst Biol Appl. 2016 Oct 27;2:16027. doi: 10.1038/npjsba.2016.27. eCollection 2016. PMID: 28725479

Crystal Structure of the Acid Sphingomyelinase-like Phosphodiesterase SMPDL3B Provides Insights into Determinants of Substrate Specificity
Gorelik A, Heinz LX, Illes K, Superti-Furga G, Nagar B.
J Biol Chem. 2016 Nov 11;291(46):24054-24064. doi: 10.1074/jbc.M116.755801. Epub 2016 Sep 28. PMID: 27687724

The Tumor Suppressor Hace1 Is a Critical Regulator of TNFR1-Mediated Cell Fate
Tortola L, Nitsch R, Bertrand MJM, Kogler M, Redouane Y, Kozieradzki I, Uribesalgo I, Fennell LM, Daugaard M, Klug H, Wirnsberger G, Wimmer R, Perlot T, Sarao R, Rao S, Hanada T, Takahashi N, Kernbauer E, Demiröz D, Lang M, Superti-Furga G, Decker T, Pichler A, Ikeda F, Kroemer G, Vandenabeele P, Sorensen PH, Penninger JM.
Cell Rep. 2016 Sep 20;16(12):3414. doi: 10.1016/j.celrep.2016.08.072. Epub 2016 Sep 20. PMID: 27653700

Crystal structure of mammalian acid sphingomyelinase
Gorelik A, Illes K, Heinz LX, Superti-Furga G, Nagar B.
Nat Commun. 2016 Jul 20;7:12196. doi: 10.1038/ncomms12196. PMID: 27435900

Identifying Kinase Substrates via a Heavy ATP Kinase Assay and Quantitative Mass Spectrometry
Müller AC, Giambruno R, Weißer J, Májek P, Hofer A, Bigenzahn JW, Superti-Furga G, Jessen HJ, Bennett KL.
Sci Rep. 2016 Jun 27;6:28107. doi: 10.1038/srep28107. PMID: 27346722

NANS-mediated synthesis of sialic acid is required for brain and skeletal development
van Karnebeek CD, Bonafé L, Wen XY, Tarailo-Graovac M, Balzano S, Royer-Bertrand B, Ashikov A, Garavelli L, Mammi I, Turolla L, Breen C, Donnai D, Cormier-Daire V, Heron D, Nishimura G, Uchikawa S, Campos-Xavier B, Rossi A, Hennet T, Brand-Arzamendi K, Rozmus J, Harshman K, Stevenson BJ, Girardi E, Superti-Furga G, Dewan T, Collingridge A, Halparin J, Ross CJ, Van Allen MI, Rossi A, Engelke UF, Kluijtmans LA, van der Heeft E, Renkema H, de Brouwer A, Huijben K, Zijlstra F, Heise T, Boltje T, Wasserman WW, Rivolta C, Unger S, Lefeber DJ, Wevers RA, Superti-Furga A.
Nat Genet. 2016 Jul;48(7):777-84. doi: 10.1038/ng.3578. Epub 2016 May 23. PMID: 27213289

Mapping the chemical chromatin reactivation landscape identifies BRD4-TAF1 cross-talk
Sdelci S, Lardeau CH, Tallant C, Klepsch F, Klaiber B, Bennett J, Rathert P, Schuster M, Penz T, Fedorov O, Superti-Furga G, Bock C, Zuber J, Huber KV, Knapp S, Müller S, Kubicek S.
Nat Chem Biol. 2016 Jul;12(7):504-10. doi: 10.1038/nchembio.2080. Epub 2016 May 9. PMID: 27159579

The Tumor Suppressor Hace1 Is a Critical Regulator of TNFR1-Mediated Cell Fate
Tortola L, Nitsch R, Bertrand MJM, Kogler M, Redouane Y, Kozieradzki I, Uribesalgo I, Fennell LM, Daugaard M, Klug H, Wirnsberger G, Wimmer R, Perlot T, Sarao R, Rao S, Hanada T, Takahashi N, Kernbauer E, Demiröz D, Lang M, Superti-Furga G, Decker T, Pichler A, Ikeda F, Kroemer G, Vandenabeele P, Sorensen PH, Penninger JM.
Cell Rep. 2016 May 17;15(7):1481-1492. doi: 10.1016/j.celrep.2016.04.032. Epub 2016 May 5. PMID: 27160902

Overcoming MITF-conferred drug resistance through dual AURKA/MAPK targeting in human melanoma cells
Pathria G, Garg B, Borgdorff V, Garg K, Wagner C, Superti-Furga G, Wagner SN.
Cell Death Dis. 2016 Mar 10;7(3):e2135. doi: 10.1038/cddis.2015.369. PMID: 26962685

An Inducible Retroviral Expression System for Tandem Affinity Purification Mass-Spectrometry-Based Proteomics Identifies Mixed Lineage Kinase Domain-like Protein (MLKL) as an Heat Shock Protein 90 (HSP90) Client
Bigenzahn JW, Fauster A, Rebsamen M, Kandasamy RK, Scorzoni S, Vladimer GI, Müller AC, Gstaiger M, Zuber J, Bennett KL, Superti-Furga G.
Mol Cell Proteomics. 2016 Mar;15(3):1139-50. doi: 10.1074/mcp.o115.055350. PMID: 26933192

Functional crosstalk between membrane lipids and TLR biology
Köberlin MS, Heinz LX, Superti-Furga G.
Curr Opin Cell Biol. 2016 Apr;39:28-36. doi: 10.1016/j.ceb.2016.01.010. Epub 2016 Feb 16. PMID: 26895312

Structural Basis for Nucleotide Hydrolysis by the Acid Sphingomyelinase-like Phosphodiesterase SMPDL3A
Gorelik A, Illes K, Superti-Furga G, Nagar B.
J Biol Chem. 2016 Mar 18;291(12):6376-85. doi: 10.1074/jbc.M115.711085. Epub 2016 Jan 20. PMID: 26792860

A Surface Biotinylation Strategy for Reproducible Plasma Membrane Protein Purification and Tracking of Genetic and Drug-Induced Alterations
Hörmann K, Stukalov A, Müller AC, Heinz LX, Superti-Furga G, Colinge J, Bennett KL.
J Proteome Res. 2016 Feb 5;15(2):647-58. doi: 10.1021/acs.jproteome.5b01066. Epub 2016 Jan 12. PMID: 26699813

Paul Ehrlich (1854-1915) and His Contributions to the Foundation and Birth of Translational Medicine
Valent P, Groner B, Schumacher U, Superti-Furga G, Busslinger M, Kralovics R, Zielinski C, Penninger JM, Kerjaschki D, Stingl G, Smolen JS, Valenta R, Lassmann H, Kovar H, Jäger U, Kornek G, Müller M, Sörgel F.
J Innate Immun. 2016;8(2):111-20. doi: 10.1159/000443526. Epub 2016 Feb 5. PMID: 26845587

Profiling of Small Molecules by Chemical Proteomics
Huber KVM, Superti-Furga G.
Methods Mol Biol. 2016;1394:211-218. doi: 10.1007/978-1-4939-3341-9_15. PMID: 26700051

Germline RBBP6 mutations in familial myeloproliferative neoplasms
Harutyunyan AS, Giambruno R, Krendl C, Stukalov A, Klampfl T, Berg T, Chen D, Milosevic Feenstra JD, Jäger R, Gisslinger B, Gisslinger H, Rumi E, Passamonti F, Pietra D, Müller AC, Parapatics K, Breitwieser FP, Herrmann R, Colinge J, Bennett KL, Superti-Furga G, Cazzola M, Hammond E, Kralovics R.
Blood. 2016 Jan 21;127(3):362-5. doi: 10.1182/blood-2015-09-668673. Epub 2015 Nov 16. PMID: 26574608

SLC38A9: A lysosomal amino acid transporter at the core of the amino acid-sensing machinery that controls MTORC1
Rebsamen M, Superti-Furga G.
Autophagy. 2016 Jun 2;12(6):1061-2. doi: 10.1080/15548627.2015.1091143. Epub 2015 Oct 2. PMID: 26431368

Target interaction profiling of midostaurin and its metabolites in neoplastic mast cells predicts distinct effects on activation and growth
Peter B, Winter GE, Blatt K, Bennett KL, Stefanzl G, Rix U, Eisenwort G, Hadzijusufovic E, Gridling M, Dutreix C, Hoermann G, Schwaab J, Radia D, Roesel J, Manley PW, Reiter A, Superti-Furga G, Valent P.
Leukemia. 2016 Feb;30(2):464-72. doi: 10.1038/leu.2015.242. Epub 2015 Sep 9. PMID: 26349526



2015


Mutations in the heat-shock protein A9 (HSPA9) gene cause the EVEN-PLUS syndrome of congenital malformations and skeletal dysplasia
Royer-Bertrand B, Castillo-Taucher S, Moreno-Salinas R, Cho TJ, Chae JH, Choi M, Kim OH, Dikoglu E, Campos-Xavier B, Girardi E, Superti-Furga G, Bonafé L, Rivolta C, Unger S, Superti-Furga A.
Sci Rep. 2015 Nov 24;5:17154. doi: 10.1038/srep17154. PMID: 26598328

Superoxide Dismutase 1 Protects Hepatocytes from Type I Interferon-Driven Oxidative Damage
Bhattacharya A, Hegazy AN, Deigendesch N, Kosack L, Cupovic J, Kandasamy RK, Hildebrandt A, Merkler D, Kühl AA, Vilagos B, Schliehe C, Panse I, Khamina K, Baazim H, Arnold I, Flatz L, Xu HC, Lang PA, Aderem A, Takaoka A, Superti-Furga G, Colinge J, Ludewig B, Löhning M, Bergthaler A.
Immunity. 2015 Nov 17;43(5):974-86. doi: 10.1016/j.immuni.2015.10.013. PMID: 26588782

Corrigendum: The promise and peril of chemical probes
Arrowsmith CH, Audia JE, Austin C, Baell J, Bennett J, Blagg J, Bountra C, Brennan PE, Brown PJ, Bunnage ME, Buser-Doepner C, Campbell RM, Carter AJ, Cohen P, Copeland RA, Cravatt B, Dahlin JL, Dhanak D, Edwards AM, Frederiksen M, Frye SV, Gray N, Grimshaw CE, Hepworth D, Howe T, Huber KV, Jin J, Knapp S, Kotz JD, Kruger RG, Lowe D, Mader MM, Marsden B, Mueller-Fahrnow A, Müller S, O'Hagan RC, Overington JP, Owen DR, Rosenberg SH, Ross R, Roth B, Schapira M, Schreiber SL, Shoichet B, Sundström M, Superti-Furga G, Taunton J, Toledo-Sherman L, Walpole C, Walters MA, Willson TM, Workman P, Young RN, Zuercher WJ.
Nat Chem Biol. 2015 Nov;11(11):887. doi: 10.1038/nchembio1115-887c. PMID: 26485080

Gene essentiality and synthetic lethality in haploid human cells
Blomen VA, Májek P, Jae LT, Bigenzahn JW, Nieuwenhuis J, Staring J, Sacco R, van Diemen FR, Olk N, Stukalov A, Marceau C, Janssen H, Carette JE, Bennett KL, Colinge J, Superti-Furga G, Brummelkamp TR.
Science. 2015 Nov 27;350(6264):1092-6. doi: 10.1126/science.aac7557. Epub 2015 Oct 15. PMID: 26472760

Erratum: Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia
Grebien F, Vedadi M, Getlik M, Giambruno R, Grover A, Avellino R, Skucha A, Vittori S, Kuznetsova E, Smil D, Barsyte-Lovejoy D, Li F, Poda G, Schapira M, Wu H, Dong A, Senisterra G, Stukalov A, Huber KV, Schönegger A, Marcellus R, Bilban M, Bock C, Brown PJ, Zuber J, Bennett KL, Al-Awar R, Delwel R, Nerlov C, Arrowsmith CH, Superti-Furga G.
Nat Chem Biol. 2015 Oct;11(10):815. doi: 10.1038/nchembio1015-815b. PMID: 26379026

Proteome-wide drug and metabolite interaction mapping by thermal-stability profiling
Huber KV, Olek KM, Müller AC, Tan CS, Bennett KL, Colinge J, Superti-Furga G.
Nat Methods. 2015 Nov;12(11):1055-7. doi: 10.1038/nmeth.3590. Epub 2015 Sep 21. PMID: 26389571

Phosphatase and tensin homolog (PTEN) in antigen-presenting cells controls Th17-mediated autoimmune arthritis
Blüml S, Sahin E, Saferding V, Goncalves-Alves E, Hainzl E, Niederreiter B, Hladik A, Lohmeyer T, Brunner JS, Bonelli M, Koenders MI, van den Berg WB, Superti-Furga G, Smolen JS, Schabbauer G, Redlich K.
Arthritis Res Ther. 2015 Aug 26;17(1):230. doi: 10.1186/s13075-015-0742-y. PMID: 26307404

The promise and peril of chemical probes
Arrowsmith CH, Audia JE, Austin C, Baell J, Bennett J, Blagg J, Bountra C, Brennan PE, Brown PJ, Bunnage ME, Buser-Doepner C, Campbell RM, Carter AJ, Cohen P, Copeland RA, Cravatt B, Dahlin JL, Dhanak D, Edwards AM, Frederiksen M, Frye SV, Gray N, Grimshaw CE, Hepworth D, Howe T, Huber KV, Jin J, Knapp S, Kotz JD, Kruger RG, Lowe D, Mader MM, Marsden B, Mueller-Fahrnow A, Müller S, O'Hagan RC, Overington JP, Owen DR, Rosenberg SH, Roth B, Ross R, Schapira M, Schreiber SL, Shoichet B, Sundström M, Superti-Furga G, Taunton J, Toledo-Sherman L, Walpole C, Walters MA, Willson TM, Workman P, Young RN, Zuercher WJ.
Nat Chem Biol. 2015 Aug;11(8):536-41. doi: 10.1038/nchembio.1867. PMID: 26196764

A Call for Systematic Research on Solute Carriers
César-Razquin A, Snijder B, Frappier-Brinton T, Isserlin R, Gyimesi G, Bai X, Reithmeier RA, Hepworth D, Hediger MA, Edwards AM, Superti-Furga G.
Cell. 2015 Jul 30;162(3):478-87. doi: 10.1016/j.cell.2015.07.022. PMID: 26232220

Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia
Grebien F, Vedadi M, Getlik M, Giambruno R, Grover A, Avellino R, Skucha A, Vittori S, Kuznetsova E, Smil D, Barsyte-Lovejoy D, Li F, Poda G, Schapira M, Wu H, Dong A, Senisterra G, Stukalov A, Huber KVM, Schönegger A, Marcellus R, Bilban M, Bock C, Brown PJ, Zuber J, Bennett KL, Al-Awar R, Delwel R, Nerlov C, Arrowsmith CH, Superti-Furga G.
Nat Chem Biol. 2015 Aug;11(8):571-578. doi: 10.1038/nchembio.1859. Epub 2015 Jul 13. PMID: 26167872

The Lipid-Modifying Enzyme SMPDL3B Negatively Regulates Innate Immunity
Heinz LX, Baumann CL, Köberlin MS, Snijder B, Gawish R, Shui G, Sharif O, Aspalter IM, Müller AC, Kandasamy RK, Breitwieser FP, Pichlmair A, Bruckner M, Rebsamen M, Blüml S, Karonitsch T, Fauster A, Colinge J, Bennett KL, Knapp S, Wenk MR, Superti-Furga G.
Cell Rep. 2015 Jun 30;11(12):1919-28. doi: 10.1016/j.celrep.2015.05.006. Epub 2015 Jun 18. PMID: 26095358
video: YouTube

A Conserved Circular Network of Coregulated Lipids Modulates Innate Immune Responses
Köberlin MS, Snijder B, Heinz LX, Baumann CL, Fauster A, Vladimer GI, Gavin AC, Superti-Furga G.
Cell. 2015 Jul 2;162(1):170-83. doi: 10.1016/j.cell.2015.05.051. Epub 2015 Jun 18. PMID: 26095250
video: vimeo
cover: Cell
press: derStandard.at

Internalization of Pseudomonas aeruginosa Strain PAO1 into Epithelial Cells Is Promoted by Interaction of a T6SS Effector with the Microtubule Network
Sana TG, Baumann C, Merdes A, Soscia C, Rattei T, Hachani A, Jones C, Bennett KL, Filloux A, Superti-Furga G, Voulhoux R, Bleves S.
mBio. 2015 Jun 2;6(3):e00712. doi: 10.1128/mBio.00712-15. PMID: 26037124

A Modular Synthesis of Modified Phosphoanhydrides
Hofer A, Cremosnik GS, Müller AC, Giambruno R, Trefzer C, Superti-Furga G, Bennett KL, Jessen HJ.
Chemistry. 2015 Jul 6;21(28):10116-22. doi: 10.1002/chem.201500838. Epub 2015 Jun 1. PMID: 26033174

Crystal structure of an SH2-kinase construct of c-Abl and effect of the SH2 domain on kinase activity
Lorenz S, Deng P, Hantschel O, Superti-Furga G, Kuriyan J.
Biochem J. 2015 Jun 1;468(2):283-91. doi: 10.1042/BJ20141492. PMID: 25779001

A cellular screen identifies ponatinib and pazopanib as inhibitors of necroptosis
Fauster A, Rebsamen M, Huber KV, Bigenzahn JW, Stukalov A, Lardeau CH, Scorzoni S, Bruckner M, Gridling M, Parapatics K, Colinge J, Bennett KL, Kubicek S, Krautwald S, Linkermann A, Superti-Furga G.
Cell Death Dis. 2015 May 21;6(5):e1767. doi: 10.1038/cddis.2015.130. PMID: 25996294

Human Haploid Cell Genetics Reveals Roles for Lipid Metabolism Genes in Nonapoptotic Cell Death
Dixon SJ, Winter GE, Musavi LS, Lee ED, Snijder B, Rebsamen M, Superti-Furga G, Stockwell BR.
ACS Chem Biol. 2015 Jul 17;10(7):1604-9. doi: 10.1021/acschembio.5b00245. Epub 2015 May 15. PMID: 25965523

KPC1-mediated ubiquitination and proteasomal processing of NF-κB1 p105 to p50 restricts tumor growth
Kravtsova-Ivantsiv Y, Shomer I, Cohen-Kaplan V, Snijder B, Superti-Furga G, Gonen H, Sommer T, Ziv T, Admon A, Naroditsky I, Jbara M, Brik A, Pikarsky E, Kwon YT, Doweck I, Ciechanover A.
Cell. 2015 Apr 9;161(2):333-47. doi: 10.1016/j.cell.2015.03.001. PMID: 25860612

Mutations in LONP1, a mitochondrial matrix protease, cause CODAS syndrome
Dikoglu E, Alfaiz A, Gorna M, Bertola D, Chae JH, Cho TJ, Derbent M, Alanay Y, Guran T, Kim OH, Llerenar JC Jr, Yamamoto G, Superti-Furga G, Reymond A, Xenarios I, Stevenson B, Campos-Xavier B, Bonafé L, Superti-Furga A, Unger S.
Am J Med Genet A. 2015 Jul;167(7):1501-9. doi: 10.1002/ajmg.a.37029. Epub 2015 Mar 21. PMID: 25808063

The RNA-binding protein HuR/ELAVL1 regulates IFN-β mRNA abundance and the type I IFN response
Herdy B, Karonitsch T, Vladimer GI, Tan CS, Stukalov A, Trefzer C, Bigenzahn JW, Theil T, Holinka J, Kiener HP, Colinge J, Bennett KL, Superti-Furga G.
Eur J Immunol. 2015 May;45(5):1500-11. doi: 10.1002/eji.201444979. Epub 2015 Mar 12. PMID: 25678110

Coincidental loss of DOCK8 function in NLRP10-deficient and C3H/HeJ mice results in defective dendritic cell migration
Krishnaswamy JK, Singh A, Gowthaman U, Wu R, Gorrepati P, Sales Nascimento M, Gallman A, Liu D, Rhebergen AM, Calabro S, Xu L, Ranney P, Srivastava A, Ranson M, Gorham JD, McCaw Z, Kleeberger SR, Heinz LX, Müller AC, Bennett KL, Superti-Furga G, Henao-Mejia J, Sutterwala FS, Williams A, Flavell RA, Eisenbarth SC.
Proc Natl Acad Sci U S A. 2015 Mar 10;112(10):3056-61. doi: 10.1073/pnas.1501554112. Epub 2015 Feb 23. PMID: 25713392

Targeting a cell state common to triple-negative breast cancers
Muellner MK, Mair B, Ibrahim Y, Kerzendorfer C, Lechtermann H, Trefzer C, Klepsch F, Müller AC, Leitner E, Macho-Maschler S, Superti-Furga G, Bennett KL, Baselga J, Rix U, Kubicek S, Colinge J, Serra V, Nijman SM.
Mol Syst Biol. 2015 Feb 19;11(1):789. doi: 10.15252/msb.20145664. PMID: 25699542

Target profiling of an antimetastatic RAPTA agent by chemical proteomics: relevance to the mode of action
Babak MV, Meier SM, Huber KVM, Reynisson J, Legin AA, Jakupec MA, Roller A, Stukalov A, Gridling M, Bennett KL, Colinge J, Berger W, Dyson PJ, Superti-Furga G, Keppler BK, Hartinger CG.
Chem Sci. 2015 Apr 1;6(4):2449-2456. doi: 10.1039/c4sc03905j. Epub 2015 Feb 9. PMID: 29308157

SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1
Rebsamen M, Pochini L, Stasyk T, de Araújo ME, Galluccio M, Kandasamy RK, Snijder B, Fauster A, Rudashevskaya EL, Bruckner M, Scorzoni S, Filipek PA, Huber KV, Bigenzahn JW, Heinz LX, Kraft C, Bennett KL, Indiveri C, Huber LA, Superti-Furga G.
Nature. 2015 Mar 26;519(7544):477-81. doi: 10.1038/nature14107. Epub 2015 Jan 7. PMID: 25561175
video: vimeo

NOTCH1 activation in breast cancer confers sensitivity to inhibition of SUMOylation
Licciardello MP, Müllner MK, Dürnberger G, Kerzendorfer C, Boidol B, Trefzer C, Sdelci S, Berg T, Penz T, Schuster M, Bock C, Kralovics R, Superti-Furga G, Colinge J, Nijman SM, Kubicek S.
Oncogene. 2015 Jul;34(29):3780-90. doi: 10.1038/onc.2014.319. Epub 2014 Sep 29. PMID: 25263445



2014


Biallelic loss-of-function mutation in NIK causes a primary immunodeficiency with multifaceted aberrant lymphoid immunity
Willmann KL, Klaver S, Doğu F, Santos-Valente E, Garncarz W, Bilic I, Mace E, Salzer E, Conde CD, Sic H, Májek P, Banerjee PP, Vladimer GI, Haskoloğlu S, Bolkent MG, Küpesiz A, Condino-Neto A, Colinge J, Superti-Furga G, Pickl WF, van Zelm MC, Eibel H, Orange JS, Ikincioğulları A, Boztuğ K.
Nat Commun. 2014 Nov 19;5:5360. doi: 10.1038/ncomms6360. PMID: 25406581

The SH2 domain regulates c-Abl kinase activation by a cyclin-like mechanism and remodulation of the hinge motion
Dölker N, Górna MW, Sutto L, Torralba AS, Superti-Furga G, Gervasio FL.
PLoS Comput Biol. 2014 Oct 9;10(10):e1003863. doi: 10.1371/journal.pcbi.1003863. eCollection 2014 Oct. PMID: 25299346

Identification of kinase inhibitor targets in the lung cancer microenvironment by chemical and phosphoproteomics
Gridling M, Ficarro SB, Breitwieser FP, Song L, Parapatics K, Colinge J, Haura EB, Marto JA, Superti-Furga G, Bennett KL, Rix U.
Mol Cancer Ther. 2014 Nov;13(11):2751-62. doi: 10.1158/1535-7163.MCT-14-0152. Epub 2014 Sep 4. PMID: 25189542

JAGN1 deficiency causes aberrant myeloid cell homeostasis and congenital neutropenia
Boztug K, Järvinen PM, Salzer E, Racek T, Mönch S, Garncarz W, Gertz EM, Schäffer AA, Antonopoulos A, Haslam SM, Schieck L, Puchałka J, Diestelhorst J, Appaswamy G, Lescoeur B, Giambruno R, Bigenzahn JW, Elling U, Pfeifer D, Conde CD, Albert MH, Welte K, Brandes G, Sherkat R, van der Werff Ten Bosch J, Rezaei N, Etzioni A, Bellanné-Chantelot C, Superti-Furga G, Penninger JM, Bennett KL, von Blume J, Dell A, Donadieu J, Klein C.
Nat Genet. 2014 Sep;46(9):1021-7. doi: 10.1038/ng.3069. Epub 2014 Aug 17. PMID: 25129144

Toward effective sharing of high-dimensional immunology data
Snijder B, Kandasamy RK, Superti-Furga G.
Nat Biotechnol. 2014 Aug;32(8):755-9. doi: 10.1038/nbt.2974. PMID: 25101748

The solute carrier SLC35F2 enables YM155-mediated DNA damage toxicity
Winter GE, Radic B, Mayor-Ruiz C, Blomen VA, Trefzer C, Kandasamy RK, Huber KVM, Gridling M, Chen D, Klampfl T, Kralovics R, Kubicek S, Fernandez-Capetillo O, Brummelkamp TR, Superti-Furga G.
Nat Chem Biol. 2014 Sep;10(9):768-773. doi: 10.1038/nchembio.1590. Epub 2014 Jul 27. PMID: 25064833

The lysine methyltransferase SMYD3 interacts with hepatitis C virus NS5A and is a negative regulator of viral particle production
Eberle CA, Zayas M, Stukalov A, Pichlmair A, Alvisi G, Müller AC, Bennett KL, Bartenschlager R, Superti-Furga G.
Virology. 2014 Aug;462-463(100):34-41. doi: 10.1016/j.virol.2014.05.016. Epub 2014 Jun 14. PMID: 25092459

Evaluating the promiscuous nature of tyrosine kinase inhibitors assessed in A431 epidermoid carcinoma cells by both chemical- and phosphoproteomics
Giansanti P, Preisinger C, Huber KV, Gridling M, Superti-Furga G, Bennett KL, Heck AJ.
ACS Chem Biol. 2014 Jul 18;9(7):1490-8. doi: 10.1021/cb500116c. Epub 2014 May 14. PMID: 24804581

Building and exploring an integrated human kinase network: global organization and medical entry points
Colinge J, César-Razquin A, Huber K, Breitwieser FP, Májek P, Superti-Furga G.
J Proteomics. 2014 Jul 31;107(100):113-27. doi: 10.1016/j.jprot.2014.03.028. Epub 2014 Apr 3. PMID: 24704859

Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy
Huber KV, Salah E, Radic B, Gridling M, Elkins JM, Stukalov A, Jemth AS, Göktürk C, Sanjiv K, Strömberg K, Pham T, Berglund UW, Colinge J, Bennett KL, Loizou JI, Helleday T, Knapp S, Superti-Furga G.
Nature. 2014 Apr 10;508(7495):222-7. doi: 10.1038/nature13194. Epub 2014 Apr 2. PMID: 24695225
video: vimeo

MMP13 mutations are the cause of recessive metaphyseal dysplasia, Spahr type
Bonafé L, Liang J, Gorna MW, Zhang Q, Ha-Vinh R, Campos-Xavier AB, Unger S, Beckmann JS, Le Béchec A, Stevenson B, Giedion A, Liu X, Superti-Furga G, Wang W, Spahr A, Superti-Furga A.
Am J Med Genet A. 2014 May;164A(5):1175-9. doi: 10.1002/ajmg.a.36431. Epub 2014 Mar 19. PMID: 24648384

IFITs: Emerging Roles as Key Anti-Viral Proteins
Vladimer GI, Górna MW, Superti-Furga G.
Front Immunol. 2014 Mar 10;5:94. doi: 10.3389/fimmu.2014.00094. eCollection 2014. PMID: 24653722

Virulence factor NSs of rift valley fever virus recruits the F-box protein FBXO3 to degrade subunit p62 of general transcription factor TFIIH
Kainulainen M, Habjan M, Hubel P, Busch L, Lau S, Colinge J, Superti-Furga G, Pichlmair A, Weber F.
J Virol. 2014 Mar;88(6):3464-73. doi: 10.1128/JVI.02914-13. Epub 2014 Jan 8. PMID: 24403578

Host-cell sensors for Plasmodium activate innate immunity against liver-stage infection
Liehl P, Zuzarte-Luís V, Chan J, Zillinger T, Baptista F, Carapau D, Konert M, Hanson KK, Carret C, Lassnig C, Müller M, Kalinke U, Saeed M, Chora AF, Golenbock DT, Strobl B, Prudêncio M, Coelho LP, Kappe SH, Superti-Furga G, Pichlmair A, Vigário AM, Rice CM, Fitzgerald KA, Barchet W, Mota MM.
Nat Med. 2014 Jan;20(1):47-53. doi: 10.1038/nm.3424. Epub 2013 Dec 22. PMID: 24362933

Viperin is an iron-sulfur protein that inhibits genome synthesis of tick-borne encephalitis virus via radical SAM domain activity
Upadhyay AS, Vonderstein K, Pichlmair A, Stehling O, Bennett KL, Dobler G, Guo JT, Superti-Furga G, Lill R, Överby AK, Weber F.
Cell Microbiol. 2014 Jun;16(6):834-48. doi: 10.1111/cmi.12241. Epub 2013 Dec 3. PMID: 24245804

A chemical biology approach identifies AMPK as a modulator of melanoma oncogene MITF
Borgdorff V, Rix U, Winter GE, Gridling M, Müller AC, Breitwieser FP, Wagner C, Colinge J, Bennett KL, Superti-Furga G, Wagner SN.
Oncogene. 2014 May 8;33(19):2531-9. doi: 10.1038/onc.2013.185. Epub 2013 Jun 3. PMID: 23728343



2013


Interactome of two diverse RNA granules links mRNA localization to translational repression in neurons
Fritzsche R, Karra D, Bennett KL, Ang FY, Heraud-Farlow JE, Tolino M, Doyle M, Bauer KE, Thomas S, Planyavsky M, Arn E, Bakosova A, Jungwirth K, Hörmann A, Palfi Z, Sandholzer J, Schwarz M, Macchi P, Colinge J, Superti-Furga G, Kiebler MA.
Cell Rep. 2013 Dec 26;5(6):1749-62. doi: 10.1016/j.celrep.2013.11.023. Epub 2013 Dec 19. PMID: 24360960

Somatic mutations of calreticulin in myeloproliferative neoplasms
Klampfl T, Gisslinger H, Harutyunyan AS, Nivarthi H, Rumi E, Milosevic JD, Them NC, Berg T, Gisslinger B, Pietra D, Chen D, Vladimer GI, Bagienski K, Milanesi C, Casetti IC, Sant'Antonio E, Ferretti V, Elena C, Schischlik F, Cleary C, Six M, Schalling M, Schönegger A, Bock C, Malcovati L, Pascutto C, Superti-Furga G, Cazzola M, Kralovics R.
N Engl J Med. 2013 Dec 19;369(25):2379-90. doi: 10.1056/NEJMoa1311347. Epub 2013 Dec 10. PMID: 24325356

Perturbation of the mutated EGFR interactome identifies vulnerabilities and resistance mechanisms
Li J, Bennett K, Stukalov A, Fang B, Zhang G, Yoshida T, Okamoto I, Kim JY, Song L, Bai Y, Qian X, Rawal B, Schell M, Grebien F, Winter G, Rix U, Eschrich S, Colinge J, Koomen J, Superti-Furga G, Haura EB.
Mol Syst Biol. 2013 Nov 5;9:705. doi: 10.1038/msb.2013.61. PMID: 24189400

A target-disease network model of second-generation BCR-ABL inhibitor action in Ph+ ALL
Rix U, Colinge J, Blatt K, Gridling M, Remsing Rix LL, Parapatics K, Cerny-Reiterer S, Burkard TR, Jäger U, Melo JV, Bennett KL, Valent P, Superti-Furga G.
PLoS One. 2013 Oct 10;8(10):e77155. doi: 10.1371/journal.pone.0077155. eCollection 2013. PMID: 24130846

A reversible gene trap collection empowers haploid genetics in human cells
Bürckstümmer T, Banning C, Hainzl P, Schobesberger R, Kerzendorfer C, Pauler FM, Chen D, Them N, Schischlik F, Rebsamen M, Smida M, Fece de la Cruz F, Lapao A, Liszt M, Eizinger B, Guenzl PM, Blomen VA, Konopka T, Gapp B, Parapatics K, Maier B, Stöckl J, Fischl W, Salic S, Taba Casari MR, Knapp S, Bennett KL, Bock C, Colinge J, Kralovics R, Ammerer G, Casari G, Brummelkamp TR, Superti-Furga G, Nijman SM.
Nat Methods. 2013 Oct;10(10):965-71. doi: 10.1038/nmeth.2609. Epub 2013 Aug 25. PMID: 24161985

Affinity purification strategies for proteomic analysis of transcription factor complexes
Giambruno R, Grebien F, Stukalov A, Knoll C, Planyavsky M, Rudashevskaya EL, Colinge J, Superti-Furga G, Bennett KL.
J Proteome Res. 2013 Sep 6;12(9):4018-27. doi: 10.1021/pr4003323. Epub 2013 Aug 22. PMID: 23937658

A miniaturized chemical proteomic approach for target profiling of clinical kinase inhibitors in tumor biopsies
Chamrád I, Rix U, Stukalov A, Gridling M, Parapatics K, Müller AC, Altiok S, Colinge J, Superti-Furga G, Haura EB, Bennett KL.
J Proteome Res. 2013 Sep 6;12(9):4005-17. doi: 10.1021/pr400309p. Epub 2013 Aug 20. PMID: 23901793

Experimental characterization of the human non-sequence-specific nucleic acid interactome
Dürnberger G, Bürckstümmer T, Huber K, Giambruno R, Doerks T, Karayel E, Burkard TR, Kaupe I, Müller AC, Schönegger A, Ecker GF, Lohninger H, Bork P, Bennett KL, Superti-Furga G, Colinge J.
Genome Biol. 2013 Jul 31;14(7):R81. doi: 10.1186/gb-2013-14-7-r81. PMID: 23902751

The CRAPome: a contaminant repository for affinity purification-mass spectrometry data
Mellacheruvu D, Wright Z, Couzens AL, Lambert JP, St-Denis NA, Li T, Miteva YV, Hauri S, Sardiu ME, Low TY, Halim VA, Bagshaw RD, Hubner NC, Al-Hakim A, Bouchard A, Faubert D, Fermin D, Dunham WH, Goudreault M, Lin ZY, Badillo BG, Pawson T, Durocher D, Coulombe B, Aebersold R, Superti-Furga G, Colinge J, Heck AJ, Choi H, Gstaiger M, Mohammed S, Cristea IM, Bennett KL, Washburn MP, Raught B, Ewing RM, Gingras AC, Nesvizhskii AI.
Nat Methods. 2013 Aug;10(8):730-6. doi: 10.1038/nmeth.2557. Epub 2013 Jul 7. PMID: 23921808

Protein interaction networks in innate immunity
Rebsamen M, Kandasamy RK, Superti-Furga G.
Trends Immunol. 2013 Dec;34(12):610-9. doi: 10.1016/j.it.2013.05.002. Epub 2013 Jul 2. PMID: 23827258

FAM111A mutations result in hypoparathyroidism and impaired skeletal development
Unger S, Górna MW, Le Béchec A, Do Vale-Pereira S, Bedeschi MF, Geiberger S, Grigelioniene G, Horemuzova E, Lalatta F, Lausch E, Magnani C, Nampoothiri S, Nishimura G, Petrella D, Rojas-Ringeling F, Utsunomiya A, Zabel B, Pradervand S, Harshman K, Campos-Xavier B, Bonafé L, Superti-Furga G, Stevenson B, Superti-Furga A.
Am J Hum Genet. 2013 Jun 6;92(6):990-5. doi: 10.1016/j.ajhg.2013.04.020. Epub 2013 May 16. PMID: 23684011

Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS
Varjosalo M, Sacco R, Stukalov A, van Drogen A, Planyavsky M, Hauri S, Aebersold R, Bennett KL, Colinge J, Gstaiger M, Superti-Furga G.
Nat Methods. 2013 Apr;10(4):307-14. doi: 10.1038/nmeth.2400. Epub 2013 Mar 3. PMID: 23455922

Structural basis for viral 5'-PPP-RNA recognition by human IFIT proteins
Abbas YM, Pichlmair A, Górna MW, Superti-Furga G, Nagar B.
Nature. 2013 Feb 7;494(7435):60-4. doi: 10.1038/nature11783. Epub 2013 Jan 13. PMID: 23334420

A method to resolve the composition of heterogeneous affinity-purified protein complexes assembled around a common protein by chemical cross-linking, gel electrophoresis and mass spectrometry
Rudashevskaya EL, Sacco R, Kratochwill K, Huber ML, Gstaiger M, Superti-Furga G, Bennett KL.
Nat Protoc. 2013 Jan;8(1):75-97. doi: 10.1038/nprot.2012.133. Epub 2012 Dec 13. PMID: 23237831



2012


Cell biology: a key driver of therapeutic innovation
Hantschel O, Superti-Furga G.
J Cell Biol. 2012 Nov 12;199(4):571-5. doi: 10.1083/jcb.201208111. PMID: 23148230

Systems-pharmacology dissection of a drug synergy in imatinib-resistant CML
Winter GE, Rix U, Carlson SM, Gleixner KV, Grebien F, Gridling M, Müller AC, Breitwieser FP, Bilban M, Colinge J, Valent P, Bennett KL, White FM, Superti-Furga G.
Nat Chem Biol. 2012 Nov;8(11):905-912. doi: 10.1038/nchembio.1085. Epub 2012 Sep 30. PMID: 23023260

The growing arsenal of ATP-competitive and allosteric inhibitors of BCR-ABL
Hantschel O, Grebien F, Superti-Furga G.
Cancer Res. 2012 Oct 1;72(19):4890-5. doi: 10.1158/0008-5472.CAN-12-1276. Epub 2012 Sep 21. PMID: 23002203

Mig6 is a sensor of EGF receptor inactivation that directly activates c-Abl to induce apoptosis during epithelial homeostasis
Hopkins S, Linderoth E, Hantschel O, Suarez-Henriques P, Pilia G, Kendrick H, Smalley MJ, Superti-Furga G, Ferby I.
Dev Cell. 2012 Sep 11;23(3):547-59. doi: 10.1016/j.devcel.2012.08.001. PMID: 22975324

Viral immune modulators perturb the human molecular network by common and unique strategies
Pichlmair A, Kandasamy K, Alvisi G, Mulhern O, Sacco R, Habjan M, Binder M, Stefanovic A, Eberle CA, Goncalves A, Bürckstümmer T, Müller AC, Fauster A, Holze C, Lindsten K, Goodbourn S, Kochs G, Weber F, Bartenschlager R, Bowie AG, Bennett KL, Colinge J, Superti-Furga G.
Nature. 2012 Jul 26;487(7408):486-90. doi: 10.1038/nature11289. PMID: 22810585

Deconvolution of targeted protein-protein interaction maps
Stukalov A, Superti-Furga G, Colinge J.
J Proteome Res. 2012 Aug 3;11(8):4102-9. doi: 10.1021/pr300137n. Epub 2012 Jul 10. PMID: 22724552

Special issue - modular protein domains
Sudol M, Cesareni G, Superti-Furga G, Just W.
FEBS Lett. 2012 Aug 14;586(17):2571. doi: 10.1016/j.febslet.2012.06.005. Epub 2012 Jun 17. PMID: 22713655

A comparative proteomic study of human skin suction blister fluid from healthy individuals using immunodepletion and iTRAQ labeling
Müller AC, Breitwieser FP, Fischer H, Schuster C, Brandt O, Colinge J, Superti-Furga G, Stingl G, Elbe-Bürger A, Bennett KL.
J Proteome Res. 2012 Jul 6;11(7):3715-27. doi: 10.1021/pr3002035. Epub 2012 May 31. PMID: 22578099

Optimisation of Downscaled Tandem Affinity Purifications to Identify Core Protein Complexes
Haura EB, Sacco R, Li J, Müller AC, Grebien F, Superti-Furga G, Bennett KL.
J Integr OMICS. 2012 May;2(1):55-68. doi: 10.5584/jiomics.v2i1.81. PMID: 24077984

SAMHD1 is a nucleic-acid binding protein that is mislocalized due to aicardi-goutières syndrome-associated mutations
Goncalves A, Karayel E, Rice GI, Bennett KL, Crow YJ, Superti-Furga G, Bürckstümmer T.
Hum Mutat. 2012 Jul;33(7):1116-22. doi: 10.1002/humu.22087. Epub 2012 Apr 16. PMID: 22461318

Plk1-dependent phosphorylation of optineurin provides a negative feedback mechanism for mitotic progression
Kachaner D, Filipe J, Laplantine E, Bauch A, Bennett KL, Superti-Furga G, Israël A, Weil R.
Mol Cell. 2012 Feb 24;45(4):553-66. doi: 10.1016/j.molcel.2011.12.030. PMID: 22365832

BCR-ABL uncouples canonical JAK2-STAT5 signaling in chronic myeloid leukemia
Hantschel O, Warsch W, Eckelhart E, Kaupe I, Grebien F, Wagner KU, Superti-Furga G, Sexl V.
Nat Chem Biol. 2012 Jan 29;8(3):285-93. doi: 10.1038/nchembio.775. PMID: 22286129

Compound immobilization and drug-affinity chromatography
Rix U, Gridling M, Superti-Furga G.
Methods Mol Biol. 2012;803:25-38. doi: 10.1007/978-1-61779-364-6_3. PMID: 22065216

Systems biology analysis of protein-drug interactions
Colinge J, Rix U, Bennett KL, Superti-Furga G.
Proteomics Clin Appl. 2012 Jan;6(1-2):102-16. doi: 10.1002/prca.201100077. Epub 2011 Dec 27. PMID: 22213655



2011


Targeting allosteric regulatory modules in oncoproteins: "drugging the undruggable"
Hantschel O, Grebien F, Superti-Furga G.
Oncotarget. 2011 Nov;2(11):828-9. doi: 10.18632/oncotarget.354. PMID: 22084171

Targeting the SH2-kinase interface in Bcr-Abl inhibits leukemogenesis
Grebien F, Hantschel O, Wojcik J, Kaupe I, Kovacic B, Wyrzucki AM, Gish GD, Cerny-Reiterer S, Koide A, Beug H, Pawson T, Valent P, Koide S, Superti-Furga G.
Cell. 2011 Oct 14;147(2):306-19. doi: 10.1016/j.cell.2011.08.046. PMID: 22000011
video: vimeo

Complement factor H binds malondialdehyde epitopes and protects from oxidative stress
Weismann D, Hartvigsen K, Lauer N, Bennett KL, Scholl HP, Charbel Issa P, Cano M, Brandstätter H, Tsimikas S, Skerka C, Superti-Furga G, Handa JT, Zipfel PF, Witztum JL, Binder CJ.
Nature. 2011 Oct 5;478(7367):76-81. doi: 10.1038/nature10449. PMID: 21979047

An integrated chemical biology approach identifies specific vulnerability of Ewing's sarcoma to combined inhibition of Aurora kinases A and B
Winter GE, Rix U, Lissat A, Stukalov A, Müllner MK, Bennett KL, Colinge J, Nijman SM, Kubicek S, Kovar H, Kontny U, Superti-Furga G.
Mol Cancer Ther. 2011 Oct;10(10):1846-56. doi: 10.1158/1535-7163.MCT-11-0100. Epub 2011 Jul 18. PMID: 21768330

Systems medicine and integrated care to combat chronic noncommunicable diseases
Bousquet J, Anto JM, Sterk PJ, Adcock IM, Chung KF, Roca J, Agusti A, Brightling C, Cambon-Thomsen A, Cesario A, Abdelhak S, Antonarakis SE, Avignon A, Ballabio A, Baraldi E, Baranov A, Bieber T, Bockaert J, Brahmachari S, Brambilla C, Bringer J, Dauzat M, Ernberg I, Fabbri L, Froguel P, Galas D, Gojobori T, Hunter P, Jorgensen C, Kauffmann F, Kourilsky P, Kowalski ML, Lancet D, Pen CL, Mallet J, Mayosi B, Mercier J, Metspalu A, Nadeau JH, Ninot G, Noble D, Oztürk M, Palkonen S, Préfaut C, Rabe K, Renard E, Roberts RG, Samolinski B, Schünemann HJ, Simon HU, Soares MB, Superti-Furga G, Tegner J, Verjovski-Almeida S, Wellstead P, Wolkenhauer O, Wouters E, Balling R, Brookes AJ, Charron D, Pison C, Chen Z, Hood L, Auffray C.
Genome Med. 2011 Jul 6;3(7):43. doi: 10.1186/gm259. PMID: 21745417

KIT-D816V-independent oncogenic signaling in neoplastic cells in systemic mastocytosis: role of Lyn and Btk activation and disruption by dasatinib and bosutinib
Gleixner KV, Mayerhofer M, Cerny-Reiterer S, Hörmann G, Rix U, Bennett KL, Hadzijusufovic E, Meyer RA, Pickl WF, Gotlib J, Horny HP, Reiter A, Mitterbauer-Hohendanner G, Superti-Furga G, Valent P.
Blood. 2011 Aug 18;118(7):1885-98. doi: 10.1182/blood-2010-06-289959. Epub 2011 Jun 16. PMID: 21680801

IFIT1 is an antiviral protein that recognizes 5'-triphosphate RNA
Pichlmair A, Lassnig C, Eberle CA, Górna MW, Baumann CL, Burkard TR, Bürckstümmer T, Stefanovic A, Krieger S, Bennett KL, Rülicke T, Weber F, Colinge J, Müller M, Superti-Furga G.
Nat Immunol. 2011 Jun 5;12(7):624-30. doi: 10.1038/ni.2048. PMID: 21642987

General statistical modeling of data from protein relative expression isobaric tags
Breitwieser FP, Müller A, Dayon L, Köcher T, Hainard A, Pichler P, Schmidt-Erfurth U, Superti-Furga G, Sanchez JC, Mechtler K, Bennett KL, Colinge J.
J Proteome Res. 2011 Jun 3;10(6):2758-66. doi: 10.1021/pr1012784. Epub 2011 May 11. PMID: 21526793

Initial characterization of the human central proteome
Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Bürckstümmer T, Bennett KL, Superti-Furga G, Colinge J.
BMC Syst Biol. 2011 Jan 26;5:17. doi: 10.1186/1752-0509-5-17. PMID: 21269460

After the grape rush: sirtuins as epigenetic drug targets in neurodegenerative disorders
Huber K, Superti-Furga G.
Bioorg Med Chem. 2011 Jun 15;19(12):3616-24. doi: 10.1016/j.bmc.2011.01.018. Epub 2011 Jan 15. PMID: 21306906

Functional dissection of the TBK1 molecular network
Goncalves A, Bürckstümmer T, Dixit E, Scheicher R, Górna MW, Karayel E, Sugar C, Stukalov A, Berg T, Kralovics R, Planyavsky M, Bennett KL, Colinge J, Superti-Furga G.
PLoS One. 2011;6(9):e23971. doi: 10.1371/journal.pone.0023971. Epub 2011 Sep 8. PMID: 21931631

Proteomic analysis of human cataract aqueous humour: Comparison of one-dimensional gel LCMS with two-dimensional LCMS of unlabelled and iTRAQ®-labelled specimens
Bennett KL, Funk M, Tschernutter M, Breitwieser FP, Planyavsky M, Ubaida Mohien C, Müller A, Trajanoski Z, Colinge J, Superti-Furga G, Schmidt-Erfurth U.
J Proteomics. 2011 Feb 1;74(2):151-66. doi: 10.1016/j.jprot.2010.10.002. Epub 2010 Oct 16. PMID: 20940065



2010


A computational approach to analyze the mechanism of action of the kinase inhibitor bafetinib
Burkard TR, Rix U, Breitwieser FP, Superti-Furga G, Colinge J.
PLoS Comput Biol. 2010 Nov 18;6(11):e1001001. doi: 10.1371/journal.pcbi.1001001. PMID: 21124949

CD14 is a coreceptor of Toll-like receptors 7 and 9
Baumann CL, Aspalter IM, Sharif O, Pichlmair A, Blüml S, Grebien F, Bruckner M, Pasierbek P, Aumayr K, Planyavsky M, Bennett KL, Colinge J, Knapp S, Superti-Furga G.
J Exp Med. 2010 Nov 22;207(12):2689-701. doi: 10.1084/jem.20101111. Epub 2010 Nov 15. PMID: 21078886

MASPECTRAS 2: An integration and analysis platform for proteomic data
Ubaida Mohien C, Hartler J, Breitwieser F, Rix U, Remsing Rix L, Winter GE, Thallinger GG, Bennett KL, Superti-Furga G, Trajanoski Z, Colinge J.
Proteomics. 2010 Jul;10(14):2719-22. doi: 10.1002/pmic.201000075. PMID: 20455215

BCR-ABL SH3-SH2 domain mutations in chronic myeloid leukemia patients on imatinib
Sherbenou DW, Hantschel O, Kaupe I, Willis S, Bumm T, Turaga LP, Lange T, Dao KH, Press RD, Druker BJ, Superti-Furga G, Deininger MW.
Blood. 2010 Oct 28;116(17):3278-85. doi: 10.1182/blood-2008-10-183665. Epub 2010 Jun 2. PMID: 20519627

Antiinflammatory effects of tumor necrosis factor on hematopoietic cells in a murine model of erosive arthritis
Blüml S, Binder NB, Niederreiter B, Polzer K, Hayer S, Tauber S, Schett G, Scheinecker C, Kollias G, Selzer E, Bilban M, Smolen JS, Superti-Furga G, Redlich K.
Arthritis Rheum. 2010 Jun;62(6):1608-19. doi: 10.1002/art.27399. PMID: 20155834

Peroxisomes are signaling platforms for antiviral innate immunity
Dixit E, Boulant S, Zhang Y, Lee AS, Odendall C, Shum B, Hacohen N, Chen ZJ, Whelan SP, Fransen M, Nibert ML, Superti-Furga G, Kagan JC.
Cell. 2010 May 14;141(4):668-81. doi: 10.1016/j.cell.2010.04.018. Epub 2010 May 6. PMID: 20451243

A potent and highly specific FN3 monobody inhibitor of the Abl SH2 domain
Wojcik J, Hantschel O, Grebien F, Kaupe I, Bennett KL, Barkinge J, Jones RB, Koide A, Superti-Furga G, Koide S.
Nat Struct Mol Biol. 2010 Apr;17(4):519-27. doi: 10.1038/nsmb.1793. Epub 2010 Mar 28. PMID: 20357770

A chemical and phosphoproteomic characterization of dasatinib action in lung cancer
Li J, Rix U, Fang B, Bai Y, Edwards A, Colinge J, Bennett KL, Gao J, Song L, Eschrich S, Superti-Furga G, Koomen J, Haura EB.
Nat Chem Biol. 2010 Apr;6(4):291-9. doi: 10.1038/nchembio.332. Epub 2010 Feb 28. PMID: 20190765

A comprehensive target selectivity survey of the BCR-ABL kinase inhibitor INNO-406 by kinase profiling and chemical proteomics in chronic myeloid leukemia cells
Rix U, Remsing Rix LL, Terker AS, Fernbach NV, Hantschel O, Planyavsky M, Breitwieser FP, Herrmann H, Colinge J, Bennett KL, Augustin M, Till JH, Heinrich MC, Valent P, Superti-Furga G.
Leukemia. 2010 Jan;24(1):44-50. doi: 10.1038/leu.2009.228. Epub 2009 Nov 5. PMID: 19890374



2009


A biomedical adventurers' guide to navigating between careers in academia and industry
Superti-Furga G.
Nat Rev Mol Cell Biol. 2009 Dec;10(12):884-7. doi: 10.1038/nrm2796. Epub 2009 Oct 27. PMID: 19859061

Immunosuppression and atypical infections in CML patients treated with dasatinib at 140 mg daily
Sillaber C, Herrmann H, Bennett K, Rix U, Baumgartner C, Böhm A, Herndlhofer S, Tschachler E, Superti-Furga G, Jäger U, Valent P.
Eur J Clin Invest. 2009 Dec;39(12):1098-109. doi: 10.1111/j.1365-2362.2009.02206.x. Epub 2009 Sep 9. PMID: 19744184

Target profiling of small molecules by chemical proteomics
Rix U, Superti-Furga G.
Nat Chem Biol. 2009 Sep;5(9):616-24. doi: 10.1038/nchembio.216. PMID: 19690537

The TLR-independent DNA recognition pathway in murine macrophages: Ligand features and molecular signature
Karayel E, Bürckstümmer T, Bilban M, Dürnberger G, Weitzer S, Martinez J, Superti-Furga G.
Eur J Immunol. 2009 Jul;39(7):1929-36. doi: 10.1002/eji.200939344. PMID: 19551900

Charting the molecular network of the drug target Bcr-Abl
Brehme M, Hantschel O, Colinge J, Kaupe I, Planyavsky M, Köcher T, Mechtler K, Bennett KL, Superti-Furga G.
Proc Natl Acad Sci U S A. 2009 May 5;106(18):7414-9. doi: 10.1073/pnas.0900653106. Epub 2009 Apr 20. PMID: 19380743

The structure of the leukemia drug imatinib bound to human quinone reductase 2 (NQO2)
Winger JA, Hantschel O, Superti-Furga G, Kuriyan J.
BMC Struct Biol. 2009 Feb 24;9:7. doi: 10.1186/1472-6807-9-7. PMID: 19236722

NSs protein of rift valley fever virus induces the specific degradation of the double-stranded RNA-dependent protein kinase
Habjan M, Pichlmair A, Elliott RM, Overby AK, Glatter T, Gstaiger M, Superti-Furga G, Unger H, Weber F.
J Virol. 2009 May;83(9):4365-75. doi: 10.1128/JVI.02148-08. Epub 2009 Feb 11. PMID: 19211744

An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome
Bürckstümmer T, Baumann C, Blüml S, Dixit E, Dürnberger G, Jahn H, Planyavsky M, Bilban M, Colinge J, Bennett KL, Superti-Furga G.
Nat Immunol. 2009 Mar;10(3):266-72. doi: 10.1038/ni.1702. Epub 2009 Jan 21. PMID: 19158679

Report on EU-USA workshop: how systems biology can advance cancer research (27 October 2008)
Aebersold R, Auffray C, Baney E, Barillot E, Brazma A, Brett C, Brunak S, Butte A, Califano A, Celis J, Cufer T, Ferrell J, Galas D, Gallahan D, Gatenby R, Goldbeter A, Hace N, Henney A, Hood L, Iyengar R, Jackson V, Kallioniemi O, Klingmüller U, Kolar P, Kolch W, Kyriakopoulou C, Laplace F, Lehrach H, Marcus F, Matrisian L, Nolan G, Pelkmans L, Potti A, Sander C, Seljak M, Singer D, Sorger P, Stunnenberg H, Superti-Furga G, Uhlen M, Vidal M, Weinstein J, Wigle D, Williams M, Wolkenhauer O, Zhivotovsky B, Zinovyev A, Zupan B.
Mol Oncol. 2009 Feb;3(1):9-17. doi: 10.1016/j.molonc.2008.11.003. Epub 2008 Dec 9. PMID: 19383362

Global target profile of the kinase inhibitor bosutinib in primary chronic myeloid leukemia cells
Remsing Rix LL, Rix U, Colinge J, Hantschel O, Bennett KL, Stranzl T, Müller A, Baumgartner C, Valent P, Augustin M, Till JH, Superti-Furga G.
Leukemia. 2009 Mar;23(3):477-85. doi: 10.1038/leu.2008.334. Epub 2008 Nov 27. PMID: 19039322



2008


A network solution
Henney A, Superti-Furga G.
Nature. 2008 Oct 9;455(7214):730-1. doi: 10.1038/455730a. PMID: 18843342

Intrinsic differences between the catalytic properties of the oncogenic NUP214-ABL1 and BCR-ABL1 fusion protein kinases
De Keersmaecker K, Versele M, Cools J, Superti-Furga G, Hantschel O.
Leukemia. 2008 Dec;22(12):2208-16. doi: 10.1038/leu.2008.242. Epub 2008 Sep 11. PMID: 18784740

Structural coupling of SH2-kinase domains links Fes and Abl substrate recognition and kinase activation
Filippakopoulos P, Kofler M, Hantschel O, Gish GD, Grebien F, Salah E, Neudecker P, Kay LE, Turk BE, Superti-Furga G, Pawson T, Knapp S.
Cell. 2008 Sep 5;134(5):793-803. doi: 10.1016/j.cell.2008.07.047. PMID: 18775312

The chemokine interleukin-8 and the surface activation protein CD69 are markers for Bcr-Abl activity in chronic myeloid leukemia
Hantschel O, Gstoettenbauer A, Colinge J, Kaupe I, Bilban M, Burkard TR, Valent P, Superti-Furga G.
Mol Oncol. 2008 Oct;2(3):272-81. doi: 10.1016/j.molonc.2008.07.003. Epub 2008 Jul 23. PMID: 19383348

Dasatinib inhibits the growth and survival of neoplastic human eosinophils (EOL-1) through targeting of FIP1L1-PDGFRalpha
Baumgartner C, Gleixner KV, Peter B, Ferenc V, Gruze A, Remsing Rix LL, Bennett KL, Samorapoompichit P, Lee FY, Pickl WF, Esterbauer H, Sillaber C, Superti-Furga G, Valent P.
Exp Hematol. 2008 Oct;36(10):1244-53. doi: 10.1016/j.exphem.2008.04.017. Epub 2008 Jul 10. PMID: 18619723

The DEAD-box helicase DDX3X is a critical component of the TANK-binding kinase 1-dependent innate immune response
Soulat D, Bürckstümmer T, Westermayer S, Goncalves A, Bauch A, Stefanovic A, Hantschel O, Bennett KL, Decker T, Superti-Furga G.
EMBO J. 2008 Aug 6;27(15):2135-46. doi: 10.1038/emboj.2008.126. Epub 2008 Jun 26. PMID: 18583960

Target spectrum of the BCR-ABL inhibitors imatinib, nilotinib and dasatinib
Hantschel O, Rix U, Superti-Furga G.
Leuk Lymphoma. 2008 Apr;49(4):615-9. doi: 10.1080/10428190801896103. PMID: 18398720

Characterization of BCR-ABL deletion mutants from patients with chronic myeloid leukemia
Sherbenou DW, Hantschel O, Turaga L, Kaupe I, Willis S, Bumm T, Press RD, Superti-Furga G, Druker BJ, Deininger MW.
Leukemia. 2008 Jun;22(6):1184-90. doi: 10.1038/leu.2008.65. Epub 2008 Mar 20. PMID: 18354488

Finally: The digital, democratic age of scientific abstracts
Superti-Furga G, Wieland F, Cesareni G.
FEBS Lett. 2008 Apr 9;582(8):1169. doi: 10.1016/j.febslet.2008.02.070. Epub 2008 Mar 6. PMID: 18328821

Human Proteinpedia enables sharing of human protein data
Mathivanan S, Ahmed M, Ahn NG, Alexandre H, Amanchy R, Andrews PC, Bader JS, Balgley BM, Bantscheff M, Bennett KL, Björling E, Blagoev B, Bose R, Brahmachari SK, Burlingame AS, Bustelo XR, Cagney G, Cantin GT, Cardasis HL, Celis JE, Chaerkady R, Chu F, Cole PA, Costello CE, Cotter RJ, Crockett D, DeLany JP, De Marzo AM, DeSouza LV, Deutsch EW, Dransfield E, Drewes G, Droit A, Dunn MJ, Elenitoba-Johnson K, Ewing RM, Van Eyk J, Faca V, Falkner J, Fang X, Fenselau C, Figeys D, Gagné P, Gelfi C, Gevaert K, Gimble JM, Gnad F, Goel R, Gromov P, Hanash SM, Hancock WS, Harsha HC, Hart G, Hays F, He F, Hebbar P, Helsens K, Hermeking H, Hide W, Hjernø K, Hochstrasser DF, Hofmann O, Horn DM, Hruban RH, Ibarrola N, James P, Jensen ON, Jensen PH, Jung P, Kandasamy K, Kheterpal I, Kikuno RF, Korf U, Körner R, Kuster B, Kwon MS, Lee HJ, Lee YJ, Lefevre M, Lehvaslaiho M, Lescuyer P, Levander F, Lim MS, Löbke C, Loo JA, Mann M, Martens L, Martinez-Heredia J, McComb M, McRedmond J, Mehrle A, Menon R, Miller CA, Mischak H, Mohan SS, Mohmood R, Molina H, Moran MF, Morgan JD, Moritz R, et al.
Nat Biotechnol. 2008 Feb;26(2):164-7. doi: 10.1038/nbt0208-164. PMID: 18259167

The effects of dasatinib on IgE receptor-dependent activation and histamine release in human basophils
Kneidinger M, Schmidt U, Rix U, Gleixner KV, Vales A, Baumgartner C, Lupinek C, Weghofer M, Bennett KL, Herrmann H, Schebesta A, Thomas WR, Vrtala S, Valenta R, Lee FY, Ellmeier W, Superti-Furga G, Valent P.
Blood. 2008 Mar 15;111(6):3097-107. doi: 10.1182/blood-2007-08-104372. Epub 2008 Jan 7. PMID: 18180381

Drugs in action
Eggert US, Superti-Furga G.
Nat Chem Biol. 2008 Jan;4(1):7-11. doi: 10.1038/nchembio0108-7. PMID: 18084271



2007


Mass spectrometry-based functional proteomics: from molecular machines to protein networks
Köcher T, Superti-Furga G.
Nat Methods. 2007 Oct;4(10):807-15. doi: 10.1038/nmeth1093. PMID: 17901870

Chemical proteomic profiles of the BCR-ABL inhibitors imatinib, nilotinib, and dasatinib reveal novel kinase and nonkinase targets
Rix U, Hantschel O, Dürnberger G, Remsing Rix LL, Planyavsky M, Fernbach NV, Kaupe I, Bennett KL, Valent P, Colinge J, Köcher T, Superti-Furga G.
Blood. 2007 Dec 1;110(12):4055-63. doi: 10.1182/blood-2007-07-102061. Epub 2007 Aug 24. PMID: 17720881

The Btk tyrosine kinase is a major target of the Bcr-Abl inhibitor dasatinib
Hantschel O, Rix U, Schmidt U, Bürckstümmer T, Kneidinger M, Schütze G, Colinge J, Bennett KL, Ellmeier W, Valent P, Superti-Furga G.
Proc Natl Acad Sci U S A. 2007 Aug 14;104(33):13283-8. doi: 10.1073/pnas.0702654104. Epub 2007 Aug 7. PMID: 17684099

The minimum information required for reporting a molecular interaction experiment (MIMIx)
Orchard S, Salwinski L, Kerrien S, Montecchi-Palazzi L, Oesterheld M, Stümpflen V, Ceol A, Chatr-aryamontri A, Armstrong J, Woollard P, Salama JJ, Moore S, Wojcik J, Bader GD, Vidal M, Cusick ME, Gerstein M, Gavin AC, Superti-Furga G, Greenblatt J, Bader J, Uetz P, Tyers M, Legrain P, Fields S, Mulder N, Gilson M, Niepmann M, Burgoon L, De Las Rivas J, Prieto C, Perreau VM, Hogue C, Mewes HW, Apweiler R, Xenarios I, Eisenberg D, Cesareni G, Hermjakob H.
Nat Biotechnol. 2007 Aug;25(8):894-8. doi: 10.1038/nbt1324. PMID: 17687370

Selective serotonin reuptake inhibitors--a new modality for the treatment of lymphoma/leukaemia?
Schuster C, Fernbach N, Rix U, Superti-Furga G, Holy M, Freissmuth M, Sitte HH, Sexl V.
Biochem Pharmacol. 2007 Nov 1;74(9):1424-35. doi: 10.1016/j.bcp.2007.07.017. Epub 2007 Jul 20. PMID: 17709099



2006


An efficient tandem affinity purification procedure for interaction proteomics in mammalian cells
Bürckstümmer T, Bennett KL, Preradovic A, Schütze G, Hantschel O, Superti-Furga G, Bauch A.
Nat Methods. 2006 Dec;3(12):1013-9. doi: 10.1038/nmeth968. Epub 2006 Oct 22. PMID: 17060908

Transgenic mouse proteomics identifies new 14-3-3-associated proteins involved in cytoskeletal rearrangements and cell signaling
Angrand PO, Segura I, Völkel P, Ghidelli S, Terry R, Brajenovic M, Vintersten K, Klein R, Superti-Furga G, Drewes G, Kuster B, Bouwmeester T, Acker-Palmer A.
Mol Cell Proteomics. 2006 Dec;5(12):2211-27. doi: 10.1074/mcp.M600147-MCP200. Epub 2006 Sep 6. PMID: 16959763

Cytoplasmic Listeria monocytogenes stimulates IFN-beta synthesis without requiring the adapter protein MAVS
Soulat D, Bauch A, Stockinger S, Superti-Furga G, Decker T.
FEBS Lett. 2006 Apr 17;580(9):2341-2346. doi: 10.1016/j.febslet.2006.03.057. PMID: 16616525

Src kinase phosphorylates Caspase-8 on Tyr380: a novel mechanism of apoptosis suppression
Cursi S, Rufini A, Stagni V, Condò I, Matafora V, Bachi A, Bonifazi AP, Coppola L, Superti-Furga G, Testi R, Barilà D.
EMBO J. 2006 May 3;25(9):1895-905. doi: 10.1038/sj.emboj.7601085. Epub 2006 Apr 13. PMID: 16619028

Charting protein complexes, signaling pathways, and networks in the immune system
Bauch A, Superti-Furga G.
Immunol Rev. 2006 Apr;210:187-207. doi: 10.1111/j.0105-2896.2006.00369.x. PMID: 16623772

Organization of the SH3-SH2 unit in active and inactive forms of the c-Abl tyrosine kinase
Nagar B, Hantschel O, Seeliger M, Davies JM, Weis WI, Superti-Furga G, Kuriyan J.
Mol Cell. 2006 Mar 17;21(6):787-98. doi: 10.1016/j.molcel.2006.01.035. PMID: 16543148

Proteome survey reveals modularity of the yeast cell machinery
Gavin AC, Aloy P, Grandi P, Krause R, Boesche M, Marzioch M, Rau C, Jensen LJ, Bastuck S, Dümpelfeld B, Edelmann A, Heurtier MA, Hoffman V, Hoefert C, Klein K, Hudak M, Michon AM, Schelder M, Schirle M, Remor M, Rudi T, Hooper S, Bauer A, Bouwmeester T, Casari G, Drewes G, Neubauer G, Rick JM, Kuster B, Bork P, Russell RB, Superti-Furga G.
Nature. 2006 Mar 30;440(7084):631-6. doi: 10.1038/nature04532. Epub 2006 Jan 22. PMID: 16429126



2005


Structural basis for the cytoskeletal association of Bcr-Abl/c-Abl
Hantschel O, Wiesner S, Güttler T, Mackereth CD, Rix LL, Mikes Z, Dehne J, Görlich D, Sattler M, Superti-Furga G.
Mol Cell. 2005 Aug 19;19(4):461-73. doi: 10.1016/j.molcel.2005.06.030. PMID: 16109371

NMR Assignment Reveals an alpha-Helical Fold for the F-Actin Binding Domain of Human Bcr-Abl/c-Abl
Wiesner S, Hantschel O, Mackereth CD, Superti-Furga G, Sattler M.
J Biomol NMR. 2005 Aug;32(4):335. doi: 10.1007/s10858-005-8868-x. PMID: 16211486



2004


RhoB and actin polymerization coordinate Src activation with endosome-mediated delivery to the membrane
Sandilands E, Cans C, Fincham VJ, Brunton VG, Mellor H, Prendergast GC, Norman JC, Superti-Furga G, Frame MC.
Dev Cell. 2004 Dec;7(6):855-69. doi: 10.1016/j.devcel.2004.09.019. PMID: 15572128

Structure-based assembly of protein complexes in yeast
Aloy P, Böttcher B, Ceulemans H, Leutwein C, Mellwig C, Fischer S, Gavin AC, Bork P, Superti-Furga G, Serrano L, Russell RB.
Science. 2004 Mar 26;303(5666):2026-9. doi: 10.1126/science.1092645. PMID: 15044803

A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway
Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G.
Nat Cell Biol. 2004 Feb;6(2):97-105. doi: 10.1038/ncb1086. Epub 2004 Jan 25. PMID: 14743216

Regulation of the c-Abl and Bcr-Abl tyrosine kinases
Hantschel O, Superti-Furga G.
Nat Rev Mol Cell Biol. 2004 Jan;5(1):33-44. doi: 10.1038/nrm1280. PMID: 14708008



2003


Rediscovering the sweet spot in drug discovery
Brown D, Superti-Furga G.
Drug Discov Today. 2003 Dec 1;8(23):1067-77. doi: 10.1016/s1359-6446(03)02902-7. PMID: 14693466

ELM server: A new resource for investigating short functional sites in modular eukaryotic proteins
Puntervoll P, Linding R, Gemünd C, Chabanis-Davidson S, Mattingsdal M, Cameron S, Martin DM, Ausiello G, Brannetti B, Costantini A, Ferrè F, Maselli V, Via A, Cesareni G, Diella F, Superti-Furga G, Wyrwicz L, Ramu C, McGuigan C, Gudavalli R, Letunic I, Bork P, Rychlewski L, Küster B, Helmer-Citterich M, Hunter WN, Aasland R, Gibson TJ.
Nucleic Acids Res. 2003 Jul 1;31(13):3625-30. doi: 10.1093/nar/gkg545. PMID: 12824381

Caspase-dependent cleavage of c-Abl contributes to apoptosis
Barilà D, Rufini A, Condò I, Ventura N, Dorey K, Superti-Furga G, Testi R.
Mol Cell Biol. 2003 Apr;23(8):2790-9. doi: 10.1128/mcb.23.8.2790-2799.2003. PMID: 12665579

Regulation of c-Fes tyrosine kinase activity by coiled-coil and SH2 domains: analysis with Saccharomyces cerevisiae
Takashima Y, Delfino FJ, Engen JR, Superti-Furga G, Smithgall TE.
Biochemistry. 2003 Apr 1;42(12):3567-74. doi: 10.1021/bi0272499. PMID: 12653561

Structural basis for the autoinhibition of c-Abl tyrosine kinase
Nagar B, Hantschel O, Young MA, Scheffzek K, Veach D, Bornmann W, Clarkson B, Superti-Furga G, Kuriyan J.
Cell. 2003 Mar 21;112(6):859-71. doi: 10.1016/s0092-8674(03)00194-6. PMID: 12654251

A myristoyl/phosphotyrosine switch regulates c-Abl
Hantschel O, Nagar B, Guettler S, Kretzschmar J, Dorey K, Kuriyan J, Superti-Furga G.
Cell. 2003 Mar 21;112(6):845-57. doi: 10.1016/s0092-8674(03)00191-0. PMID: 12654250

Protein complexes and proteome organization from yeast to man
Gavin AC, Superti-Furga G.
Curr Opin Chem Biol. 2003 Feb;7(1):21-7. doi: 10.1016/s1367-5931(02)00007-8. PMID: 12547422



2002


Phosphorylation of Bruton's tyrosine kinase by c-Abl
Bäckesjö CM, Vargas L, Superti-Furga G, Smith CI.
Biochem Biophys Res Commun. 2002 Dec 6;299(3):510-5. doi: 10.1016/s0006-291x(02)02643-8. PMID: 12445832

High-affinity Src-SH2 ligands which do not activate Tyr(527)-phosphorylated Src in an experimental in vivo system
Mandine E, Jean-Baptiste V, Vayssière B, Gofflo D, Bénard D, Sarubbi E, Deprez P, Baron R, Superti-Furga G, Lesuisse D.
Biochem Biophys Res Commun. 2002 Oct 25;298(2):185-92. doi: 10.1016/s0006-291x(02)02424-5. PMID: 12387813

A complex prediction: three-dimensional model of the yeast exosome
Aloy P, Ciccarelli FD, Leutwein C, Gavin AC, Superti-Furga G, Bork P, Bottcher B, Russell RB.
EMBO Rep. 2002 Jul;3(7):628-35. doi: 10.1093/embo-reports/kvf135. PMID: 12101094

c-Src-mediated phosphorylation of hnRNP K drives translational activation of specifically silenced mRNAs
Ostareck-Lederer A, Ostareck DH, Cans C, Neubauer G, Bomsztyk K, Superti-Furga G, Hentze MW.
Mol Cell Biol. 2002 Jul;22(13):4535-43. doi: 10.1128/mcb.22.13.4535-4543.2002. PMID: 12052863

c-Abl is an effector of Src for growth factor-induced c-myc expression and DNA synthesis
Furstoss O, Dorey K, Simon V, Barilà D, Superti-Furga G, Roche S.
EMBO J. 2002 Feb 15;21(4):514-24. doi: 10.1093/emboj/21.4.514. PMID: 11847100

Autoinhibition of c-Abl
Pluk H, Dorey K, Superti-Furga G.
Cell. 2002 Jan 25;108(2):247-59. doi: 10.1016/s0092-8674(02)00623-2. PMID: 11832214

Functional organization of the yeast proteome by systematic analysis of protein complexes
Gavin AC, Bösche M, Krause R, Grandi P, Marzioch M, Bauer A, Schultz J, Rick JM, Michon AM, Cruciat CM, Remor M, Höfert C, Schelder M, Brajenovic M, Ruffner H, Merino A, Klein K, Hudak M, Dickson D, Rudi T, Gnau V, Bauch A, Bastuck S, Huhse B, Leutwein C, Heurtier MA, Copley RR, Edelmann A, Querfurth E, Rybin V, Drewes G, Raida M, Bouwmeester T, Bork P, Seraphin B, Kuster B, Neubauer G, Superti-Furga G.
Nature. 2002 Jan 10;415(6868):141-7. doi: 10.1038/415141a. PMID: 11805826



2001


Phosphorylation and structure-based functional studies reveal a positive and a negative role for the activation loop of the c-Abl tyrosine kinase
Dorey K, Engen JR, Kretzschmar J, Wilm M, Neubauer G, Schindler T, Superti-Furga G.
Oncogene. 2001 Dec 6;20(56):8075-84. doi: 10.1038/sj.onc.1205017. PMID: 11781820

Dynamic coupling between the SH2 and SH3 domains of c-Src and Hck underlies their inactivation by C-terminal tyrosine phosphorylation
Young MA, Gonfloni S, Superti-Furga G, Roux B, Kuriyan J.
Cell. 2001 Apr 6;105(1):115-26. doi: 10.1016/s0092-8674(01)00301-4. PMID: 11301007



2000


Nuclear tyrosine phosphorylation: the beginning of a map
Cans C, Mangano R, Barilá D, Neubauer G, Superti-Furga G.
Biochem Pharmacol. 2000 Oct 15;60(8):1203-15. doi: 10.1016/s0006-2952(00)00434-2. PMID: 11007959

Myotubularin, a phosphatase deficient in myotubular myopathy, acts on phosphatidylinositol 3-kinase and phosphatidylinositol 3-phosphate pathway
Blondeau F, Laporte J, Bodin S, Superti-Furga G, Payrastre B, Mandel JL.
Hum Mol Genet. 2000 Sep 22;9(15):2223-9. doi: 10.1093/oxfordjournals.hmg.a018913. PMID: 11001925

Crosstalk between the catalytic and regulatory domains allows bidirectional regulation of Src
Gonfloni S, Weijland A, Kretzschmar J, Superti-Furga G.
Nat Struct Biol. 2000 Apr;7(4):281-6. doi: 10.1038/74041. PMID: 10742171

A nuclear tyrosine phosphorylation circuit: c-Jun as an activator and substrate of c-Abl and JNK
Barilá D, Mangano R, Gonfloni S, Kretzschmar J, Moro M, Bohmann D, Superti-Furga G.
EMBO J. 2000 Jan 17;19(2):273-81. doi: 10.1093/emboj/19.2.273. PMID: 10637231



1999


Actin-based motility of vaccinia virus mimics receptor tyrosine kinase signalling
Frischknecht F, Moreau V, Röttger S, Gonfloni S, Reckmann I, Superti-Furga G, Way M.
Nature. 1999 Oct 28;401(6756):926-9. doi: 10.1038/44860. PMID: 10553910

Leucine 255 of Src couples intramolecular interactions to inhibition of catalysis
Gonfloni S, Frischknecht F, Way M, Superti-Furga G.
Nat Struct Biol. 1999 Aug;6(8):760-4. doi: 10.1038/11537. PMID: 10426955

Serine and tyrosine phosphorylations cooperate in Raf-1, but not B-Raf activation
Mason CS, Springer CJ, Cooper RG, Superti-Furga G, Marshall CJ, Marais R.
EMBO J. 1999 Apr 15;18(8):2137-48. doi: 10.1093/emboj/18.8.2137. PMID: 10205168

Regulation of human c-Abl tyrosine kinase activity in Xenopus oocytes and acceleration of progesterone-induced G2/M transition by oncogenic forms
Dorey K, Barilá D, Gavin AC, Nebreda AR, Superti-Furga G.
Biol Chem. 1999 Feb;380(2):223-30. doi: 10.1515/BC.1999.030. PMID: 10195429



1998


An intramolecular SH3-domain interaction regulates c-Abl activity
Barilá D, Superti-Furga G.
Nat Genet. 1998 Mar;18(3):280-2. doi: 10.1038/ng0398-280. PMID: 9500553



1997


The 2.35 A crystal structure of the inactivated form of chicken Src: a dynamic molecule with multiple regulatory interactions
Williams JC, Weijland A, Gonfloni S, Thompson A, Courtneidge SA, Superti-Furga G, Wierenga RK.
J Mol Biol. 1997 Dec 19;274(5):757-75. doi: 10.1006/jmbi.1997.1426. PMID: 9405157

The role of the linker between the SH2 domain and catalytic domain in the regulation and function of Src
Gonfloni S, Williams JC, Hattula K, Weijland A, Wierenga RK, Superti-Furga G.
EMBO J. 1997 Dec 15;16(24):7261-71. doi: 10.1093/emboj/16.24.7261. PMID: 9405355

A crystal milestone: the structure of regulated Src
Superti-Furga G, Gonfloni S.
Bioessays. 1997 Jun;19(6):447-50. doi: 10.1002/bies.950190602. PMID: 9204760

Alternative splicing of the human CDC25B tyrosine phosphatase. Possible implications for growth control?
Baldin V, Cans C, Superti-Furga G, Ducommun B.
Oncogene. 1997 May 22;14(20):2485-95. doi: 10.1038/sj.onc.1201063. PMID: 9188863

Src regulated by C-terminal phosphorylation is monomeric
Weijland A, Williams JC, Neubauer G, Courtneidge SA, Wierenga RK, Superti-Furga G.
Proc Natl Acad Sci U S A. 1997 Apr 15;94(8):3590-5. doi: 10.1073/pnas.94.8.3590. PMID: 9108021

A functional screen for regulators of the c-Abl protein tyrosine kinase
Moro M, Walkenhorst J, Goga A, Witte ON, Superti-Furga G.
Leukemia. 1997 Apr;11 Suppl 3:313-5. PMID: 9209375

The five cleavage-stage (CS) histones of the sea urchin are encoded by a maternally expressed family of replacement histone genes: functional equivalence of the CS H1 and frog H1M (B4) proteins
Mandl B, Brandt WF, Superti-Furga G, Graninger PG, Birnstiel ML, Busslinger M.
Mol Cell Biol. 1997 Mar;17(3):1189-200. doi: 10.1128/mcb.17.3.1189. PMID: 9032246

Opposite effects of the p52shc/p46shc and p66shc splicing isoforms on the EGF receptor-MAP kinase-fos signalling pathway
Migliaccio E, Mele S, Salcini AE, Pelicci G, Lai KM, Superti-Furga G, Pawson T, Di Fiore PP, Lanfrancone L, Pelicci PG.
EMBO J. 1997 Feb 17;16(4):706-16. doi: 10.1093/emboj/16.4.706. PMID: 9049300



1996


The fission yeast pmk1+ gene encodes a novel mitogen-activated protein kinase homolog which regulates cell integrity and functions coordinately with the protein kinase C pathway
Toda T, Dhut S, Superti-Furga G, Gotoh Y, Nishida E, Sugiura R, Kuno T.
Mol Cell Biol. 1996 Dec;16(12):6752-64. doi: 10.1128/mcb.16.12.6752. PMID: 8943330

The purification and characterization of the catalytic domain of Src expressed in Schizosaccharomyces pombe. Comparison of unphosphorylated and tyrosine phosphorylated species
Weijland A, Neubauer G, Courtneidge SA, Mann M, Wierenga RK, Superti-Furga G.
Eur J Biochem. 1996 Sep 15;240(3):756-64. doi: 10.1111/j.1432-1033.1996.0756h.x. PMID: 8856081

Growth controllers knocked out
Superti-Furga G.
Trends Genet. 1996 Aug;12(8):324-5. doi: 10.1016/0168-9525(96)81466-1. PMID: 8783946

A functional screen in yeast for regulators and antagonizers of heterologous protein tyrosine kinases
Superti-Furga G, Jönsson K, Courtneidge SA.
Nat Biotechnol. 1996 May;14(5):600-5. doi: 10.1038/nbt0596-600. PMID: 9630950

Analysis of human c-Abl tyrosine kinase activity and regulation in S. pombe
Walkenhorst J, Goga A, Witte ON, Superti-Furga G.
Oncogene. 1996 Apr 4;12(7):1513-20. PMID: 8622867



1995


Structural requirements for the efficient regulation of the Src protein tyrosine kinase by Csk
Koegl M, Courtneidge SA, Superti-Furga G.
Oncogene. 1995 Dec 7;11(11):2317-29. PMID: 8570183

Regulation of the Src protein tyrosine kinase
Superti-Furga G.
FEBS Lett. 1995 Aug 1;369(1):62-6. doi: 10.1016/0014-5793(95)00636-n. PMID: 7641886

Structure-function relationships in Src family and related protein tyrosine kinases
Superti-Furga G, Courtneidge SA.
Bioessays. 1995 Apr;17(4):321-30. doi: 10.1002/bies.950170408. PMID: 7537961

Mutational analysis of the Src SH3 domain: the same residues of the ligand binding surface are important for intra- and intermolecular interactions
Erpel T, Superti-Furga G, Courtneidge SA.
EMBO J. 1995 Mar 1;14(5):963-75. PMID: 7534229



1993


Csk inhibition of c-Src activity requires both the SH2 and SH3 domains of Src
Superti-Furga G, Fumagalli S, Koegl M, Courtneidge SA, Draetta G.
EMBO J. 1993 Jul;12(7):2625-34. PMID: 7687537

The Src family of protein tyrosine kinases: regulation and functions
Courtneidge SA, Fumagalli S, Koegl M, Superti-Furga G, Twamley-Stein GM.
Dev Suppl. 1993:57-64. PMID: 8049488



1992


Identification of Fos target genes by the use of selective induction systems
Braselmann S, Bergers G, Wrighton C, Graninger P, Superti-Furga G, Busslinger M.
J Cell Sci Suppl. 1992;16:97-109. doi: 10.1242/jcs.1992.supplement_16.12. PMID: 1297655



1991


Hormone-dependent transcriptional regulation and cellular transformation by Fos-steroid receptor fusion proteins
Superti-Furga G, Bergers G, Picard D, Busslinger M.
Proc Natl Acad Sci U S A. 1991 Jun 15;88(12):5114-8. doi: 10.1073/pnas.88.12.5114. PMID: 1711219



1989


The testis-specific octamer-binding protein of the sea urchin has a molecular weight of 85 kDa
Barberis A, Superti-Furga G, Busslinger M.
Nucleic Acids Res. 1989 Sep 12;17(17):7114. doi: 10.1093/nar/17.17.7114. PMID: 2780325

The deletion of the distal CCAAT box region of the A gamma-globin gene in black HPFH abolishes the binding of the erythroid specific protein NFE3 and of the CCAAT displacement protein
Mantovani R, Superti-Furga G, Gilman J, Ottolenghi S.
Nucleic Acids Res. 1989 Aug 25;17(16):6681-91. doi: 10.1093/nar/17.16.6681. PMID: 2476717

Developmental and tissue-specific regulation of a novel transcription factor of the sea urchin
Barberis A, Superti-Furga G, Vitelli L, Kemler I, Busslinger M.
Genes Dev. 1989 May;3(5):663-75. doi: 10.1101/gad.3.5.663. PMID: 2744459

The protein CDP, but not CP1, footprints on the CCAAT region of the gamma-globin gene in unfractionated B-cell extracts
Superti-Furga G, Barberis A, Schreiber E, Busslinger M.
Biochim Biophys Acta. 1989 Mar 1;1007(2):237-42. doi: 10.1016/0167-4781(89)90046-8. PMID: 2784063



1988


The -117 mutation in Greek HPFH affects the binding of three nuclear factors to the CCAAT region of the gamma-globin gene
Superti-Furga G, Barberis A, Schaffner G, Busslinger M.
EMBO J. 1988 Oct;7(10):3099-107. PMID: 3181130



1987


Mutually exclusive interaction of the CCAAT-binding factor and of a displacement protein with overlapping sequences of a histone gene promoter
Barberis A, Superti-Furga G, Busslinger M.
Cell. 1987 Jul 31;50(3):347-59. doi: 10.1016/0092-8674(87)90489-2. PMID: 3607873